Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Sign Up to like & getrecommendations! Published in 2024 at "Amino Acids"
DOI: 10.1007/s00726-023-03367-1
Abstract: Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has… read more here.
Keywords: binding; active site; structural insights; potential binding ... See more keywords
Unveiling the Potential Binding Targets of Celastrol in Colorectal Cancer: A Proteomic Profiling Approach Integrating Cellular Thermal Shift Assay and Pulse Proteolysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.4c00738
Abstract: Celastrol, a natural compound classified as a pentacyclic triterpenoid, has demonstrated efficacy in inhibiting human colorectal cancer cells’ growth, adhesion, and metastasis through various signaling pathways. However, the specific protein target responsible for the effects… read more here.
Keywords: colorectal cancer; cancer; thermal shift; shift assay ... See more keywords
Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26216423
Abstract: In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR. The similarity search of icotinib, almonertinib, and olmutinib against a database of… read more here.
Keywords: similarity; binding modes; study; almonertinib olmutinib ... See more keywords