Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7489
Abstract: This study investigated the vasorelaxant effects of schwarzinicine A, an alkaloid recently reported from Ficus schwarzii Koord. Regulation of calcium homeostasis in vascular smooth muscle cells (VSMC) is viewed as one of the main mechanisms… read more here.
Keywords: calcium; transient receptor; receptor potential; potential canonical ... See more keywords
Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/4904696
Abstract: Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but… read more here.
Keywords: receptor potential; thioredoxin effects; thioredoxin; injected mice ... See more keywords
Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System.
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DOI: 10.2174/1389450117666151209120007
Abstract: BACKGROUND Ca2+ influx plays an essential role in the physiological and pathophysiologic processes of several nervous system diseases. The transient receptor-potential channels (TRPCs) form a family of voltage -sensitive calcium ion channels. OBJECTIVE In this… read more here.
Keywords: system; receptor potential; nervous system; transient receptor ... See more keywords
Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurogastroenterology and Motility"
DOI: 10.5056/jnm20064
Abstract: Background/Aims To investigate an effect of ML204 (an inhibitor of transient receptor potential canonical 4 and 5 [TRPC4/5] channels) on interstitial cells of Cajal (ICCs) and therefore determine whether TRPC4/5 channels act on ICC-generated pacemaker… read more here.
Keywords: interstitial cells; pacemaker; receptor potential; ml204 ... See more keywords