Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09476-w
Abstract: ObjectiveMany genomic loci have been identified for multiple sclerosis (MS) by genome-wide association studies (GWAS). Discrimination of the most functionally relevant genes in these loci remains challenging. The aim of this study was to highlight… read more here.
Keywords: integrative analysis; micb granzyme; causal; multiple sclerosis ... See more keywords
Associations between potential causal factors and colorectal cancer risk: A systematic review and meta‐analysis of Mendelian randomization studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.13130
Abstract: To summarize the associations between potential causal factors and colorectal cancer (CRC) risk based on existing Mendelian randomization studies. read more here.
Keywords: causal factors; mendelian randomization; factors colorectal; colorectal cancer ... See more keywords
Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships
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DOI: 10.1177/2167702620917458
Abstract: There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-persons and within-person components to gain greater clarity about this… read more here.
Keywords: depressive symptoms; within persons; inflammatory biomarkers; associations inflammatory ... See more keywords
Exploring Potential Causal Genes for Uterine Leiomyomas: A Summary Data-Based Mendelian Randomization and FUMA Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.890007
Abstract: Objective: To explore potential causal genetic variants and genes underlying the pathogenesis of uterine leiomyomas (ULs). Methods: We conducted the summary data-based Mendelian randomization (SMR) analyses and performed functional mapping and annotation using FUMA to… read more here.
Keywords: based mendelian; analysis; uterine leiomyomas; data based ... See more keywords