Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09476-w
Abstract: ObjectiveMany genomic loci have been identified for multiple sclerosis (MS) by genome-wide association studies (GWAS). Discrimination of the most functionally relevant genes in these loci remains challenging. The aim of this study was to highlight… read more here.
Keywords: integrative analysis; micb granzyme; causal; multiple sclerosis ... See more keywords
Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color
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DOI: 10.1038/s41467-024-49031-4
Abstract: Evidence for adaptation of human skin color to regional ultraviolet radiation suggests shared and distinct genetic variants across populations. However, skin color evolution and genetics in East Asians are understudied. We quantified skin color in… read more here.
Keywords: genomic loci; potential causal; causal genes; color ... See more keywords
Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58129-2
Abstract: Metabolites are small molecules that are useful for estimating disease risk and elucidating disease biology. Here, we perform two-sample Mendelian randomization to systematically infer the potential causal effects of 1099 plasma metabolites measured in 6136… read more here.
Keywords: disease; disease endpoints; effects 1099; potential causal ... See more keywords
Exploring the potential causal association between genetic factors for multiple sclerosis and genetic factors for kidney disease: A multivariate Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2025 at "Medicine"
DOI: 10.1097/md.0000000000043247
Abstract: The potential causal relationship between genetic susceptibility to multiple sclerosis (MS) and the risk of kidney diseases remains unclear. Understanding this association may provide new insights into comorbidity mechanisms and improve clinical risk assessment. A… read more here.
Keywords: association; potential causal; mendelian randomization; genetic factors ... See more keywords
Associations between potential causal factors and colorectal cancer risk: A systematic review and meta‐analysis of Mendelian randomization studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.13130
Abstract: To summarize the associations between potential causal factors and colorectal cancer (CRC) risk based on existing Mendelian randomization studies. read more here.
Keywords: causal factors; mendelian randomization; factors colorectal; colorectal cancer ... See more keywords
Abstract 4136285: Large-Scale Proteomics Identifies Novel Shared Biomarkers of Heart Failure and Cancer: the Atherosclerosis Risk in Communities (ARIC) Study
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4136285
Abstract: Introduction: There is a bidirectional relationship between cancer and cardiovascular disease risk. Identifying proteins associated with both cancer and heart failure (HF) may provide insight into common biological pathways underlying both conditions. Methods: Among 10,136… read more here.
Keywords: cancer; lung; study; potential causal ... See more keywords
Abstract 4146394: Plasma proteomics reveals the potential causal impact of ECM proteins on abdominal aortic aneurysm
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4146394
Abstract: Background: Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. Genetic studies have identified numerous associated loci, many potentially encoding plasma proteins. However, the causal effects of plasma proteins on AAA have not… read more here.
Keywords: plasma; plasma proteins; abdominal aortic; potential causal ... See more keywords
Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Psychological Science"
DOI: 10.1177/2167702620917458
Abstract: There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-persons and within-person components to gain greater clarity about this… read more here.
Keywords: depressive symptoms; within persons; inflammatory biomarkers; associations inflammatory ... See more keywords
Exploring Potential Causal Genes for Uterine Leiomyomas: A Summary Data-Based Mendelian Randomization and FUMA Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.890007
Abstract: Objective: To explore potential causal genetic variants and genes underlying the pathogenesis of uterine leiomyomas (ULs). Methods: We conducted the summary data-based Mendelian randomization (SMR) analyses and performed functional mapping and annotation using FUMA to… read more here.
Keywords: based mendelian; analysis; uterine leiomyomas; data based ... See more keywords
Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2024.1450735
Abstract: Background Cytokines are powerful immune response factors that operate at inflammation sites and are also found in the blood. Nevertheless, research on encephalitis and these circulating inflammatory proteins is quite limited. Methods This study investigated… read more here.
Keywords: encephalitis; inflammatory proteins; circulating inflammatory; analysis ... See more keywords