Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04190j
Abstract: Betulinic acid (BA), a pentacyclic triterpenoid natural product, has received considerable attention owing to the broad spectrum of biological activities such as anti-HIV, anti-inflammatory, and especially, antitumor. Despite numerous studies on the antitumor mechanisms over… read more here.
Keywords: potential cellular; competitive affinity; proteome profiling; betulinic acid ... See more keywords
SP0111 POTENTIAL CELLULAR AND MOLECULAR TARGETS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.8460
Abstract: The pathophysiology of systemic sclerosis (SSc) is characterized by a cascade of microvascular injury with apoptosis of endothelial cells, Th2/M2 biased inflammation and autoimmunity and aberrant fibroblast activation with excessive matrix deposition. We increasingly recognize… read more here.
Keywords: potential cellular; sp0111 potential; cellular molecular; activation ... See more keywords
Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Aging and Disease"
DOI: 10.14336/ad.2017.0724
Abstract: Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the… read more here.
Keywords: cellular mechanisms; notoginseng prevention; potential cellular; panax notoginseng ... See more keywords
Potential of Cellular Therapy for ALS: Current Strategies and Future Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.851613
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive upper and lower motor neuron (MN) degeneration with unclear pathology. The worldwide prevalence of ALS is approximately 4.42 per 100,000 populations, and death… read more here.
Keywords: therapy als; als current; current strategies; therapy ... See more keywords