Construction of a lung adenocarcinoma prognostic model based on N6-methyl-adenosine-related long noncoding RNA and screening of potential drugs based on this model
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DOI: 10.1097/cad.0000000000001277
Abstract: Supplemental Digital Content is available in the text. Lung adenocarcinoma (LUAD) has a high mortality rate. N6-methyl-adenosine (m6A)-related long noncoding RNA (lncRNA) is associated with tumor prognosis. Our objective was to construct an m6A-related lncRNA… read more here.
Keywords: m6a related; luad; risk; model ... See more keywords
Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future
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DOI: 10.1124/dmd.122.000860
Abstract: Xenobiotic receptors, such as the pregnane X receptor, regulate multiple host physiologic pathways including xenobiotic metabolism, certain aspects of cellular metabolism, and innate immunity. These ligand-dependent nuclear factors regulate gene expression via genomic recognition of… read more here.
Keywords: drugs future; metabolism; metabolites ligands; microbial metabolites ... See more keywords
Integrated Bioinformatics Analysis for the Identification of Key lncRNAs, mRNAs, and Potential Drugs in Clear Cell Renal Cell Carcinomas
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DOI: 10.2147/ijgm.s409711
Abstract: Purpose The overall survival of clear cell renal cell carcinoma (ccRCC) is poor. Markers for early detection and progression could improve disease outcomes. This study aims to reveal the potential pathogenesis of ccRCC by integrative… read more here.
Keywords: bioinformatics analysis; ccrcc; analysis; clear cell ... See more keywords
Therapeutic Potential of Drugs Targeting Pathophysiology of Intracerebral Hemorrhage: From Animal Models to Clinical Applications.
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DOI: 10.2174/1381612822666161027151624
Abstract: BACKGROUND Intracerebral hemorrhage (ICH) is one of the most common forms of cerebral hemorrhage, the morbidity and death of ICH is high worldwide. ICH can be spontaneous or caused by hypertension, coagulopathy, angiopathy, head trauma,… read more here.
Keywords: intracerebral hemorrhage; hemorrhage; pathophysiology; therapeutic potential ... See more keywords
Experimental Models for Aging and their Potential for Novel Drug Discovery
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DOI: 10.2174/1570159x15666170707155345
Abstract: Background: An interesting area of scientific research is the development of potential antiaging drugs. In order to pursue this goal, it is necessary to gather the specific knowledge about the adequate preclinical models that are… read more here.
Keywords: research; experimental models; drug; preclinical models ... See more keywords
A Computational Framework to Identify Biomarkers for Glioma Recurrence and Potential Drugs Targeting Them
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DOI: 10.3389/fgene.2021.832627
Abstract: Background: Recurrence is still a major obstacle to the successful treatment of gliomas. Understanding the underlying mechanisms of recurrence may help for developing new drugs to combat gliomas recurrence. This study provides a strategy to… read more here.
Keywords: expression; gliomas; tumor samples; recurrence ... See more keywords
Identification and validation of hub genes and potential drugs involved in osteoarthritis through bioinformatics analysis
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DOI: 10.3389/fgene.2023.1117713
Abstract: Purpose: Osteoarthritis (OA) is a common degenerative disease, which still lacks specific therapeutic drugs. Synovitis is one of the most important pathological process in OA. Therefore, we aim to identify and analyze the hub genes… read more here.
Keywords: hub genes; hub; bioinformatics analysis; validation ... See more keywords
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs
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DOI: 10.3389/fmicb.2018.00320
Abstract: Animal venoms are a mixture of peptides and proteins that serve two basic biological functions: predation and defense against both predators and microbes. Antimicrobial peptides (AMPs) are a common component extensively present in various scorpion… read more here.
Keywords: multifunctionality; mesobuthus venom; activity; antimicrobial peptides ... See more keywords
Comprehensive Analysis of Endoplasmic Reticulum Stress in Intracranial Aneurysm
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DOI: 10.3389/fncel.2022.865005
Abstract: Background Aberrant endoplasmic reticulum stress (ERS) plays an important role in multiple cardiovascular diseases. However, their implication in intracranial aneurysms (IAs) remains unclear. We designed this study to explore the general expression pattern and potential… read more here.
Keywords: reticulum stress; endoplasmic reticulum; analysis; potential drugs ... See more keywords
Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications
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DOI: 10.3390/ph15091092
Abstract: Human immunodeficiency virus (HIV) infection is a major problem for humanity because HIV is constantly changing and developing resistance to current drugs. This necessitates the development of new anti-HIV drugs that take new approaches to… read more here.
Keywords: hybrid molecules; hiv; molecules potential; treatment hiv ... See more keywords