Identification of potential dual -targets anti- toxoplasma gondii compounds through structure-based virtual screening and in-vitro studies
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DOI: 10.1371/journal.pone.0225232
Abstract: Toxoplasma gondii is the etiologic agent of toxoplasmosis, a disease which can lead to morbidity and mortality of the fetus and immunocompromised individuals. Due to the limited effectiveness or side effects of existing drugs, the… read more here.
Keywords: dual targets; potential dual; structure based; identification potential ... See more keywords
Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches
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DOI: 10.3390/molecules27123888
Abstract: Coumarin derivatives are proven for their therapeutic uses in several human diseases and disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial infections. Coumarin derivatives and coumarin-based scaffolds gained renewed attention for treating diabetes… read more here.
Keywords: glucosidase amylase; coumarin; coumarin derivatives; hyperglycemia ... See more keywords