A simple, sensitive, and straightforward LC-MS approach for rapid analysis of three potential genotoxic impurities in rabeprazole formulations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201800626
Abstract: In the present study, a sensitive and fully validated liquid chromatography with mass spectrometry method was developed for the quantification of three potential genotoxic impurities in rabeprazole drug substance. The separation was achieved on Symmetry… read more here.
Keywords: simple sensitive; potential genotoxic; impurities rabeprazole; three potential ... See more keywords
Chemometrically assisted development and validation of LC–MS/MS method for the analysis of potential genotoxic impurities in meropenem active pharmaceutical ingredient
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.06.061
Abstract: Graphical abstract Figure. No Caption available. HighlightsNovel LC–MS/MS method for simultaneous determination of 3 PGIs in meropenem API.A Box‐Behnken design was utilized for method development.Grid point search methodology was implemented aiming to obtain the optimal… read more here.
Keywords: methodology; potential genotoxic; analysis; method ... See more keywords
Development and Validation of a Sensitive GC-MS/MS Method for the Determination of Five Potential Genotoxic Impurities in Abiraterone Acetate.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmab052
Abstract: A sensitive and selective gas chromatography-tandem mass spectrometry method was developed for the identification and quantification of five potential genotoxic impurities (PGIs), i.e., chloromethane, 2-chloropropane, 2-bromopropane, 4-chloro-1-butanol and diethyl sulfate, in abiraterone acetate. The method… read more here.
Keywords: potential genotoxic; abiraterone acetate; method; five potential ... See more keywords