Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: potential implications for SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12068
Abstract: Vascular endothelial cell dysfunction is reported in severe COVID-19 disease, however controversy exists regarding levels of ACE2 expression, a coreceptor for SarsCov2, in these cells. We report ACE2 expression and positive regulation by both IL-6,… read more here.
Keywords: pulmonary artery; ace2 expression; potential implications; artery endothelial ... See more keywords
Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0614-5
Abstract: Background and AimsIn this study, we evaluate the performance of allometric concepts to predict the implications of age and size on the pharmacokinetics of lamotrigine, and assess the dose rationale across different age groups from… read more here.
Keywords: age related; age; implications maintenance; lamotrigine potential ... See more keywords
Mitohormesis; Potential implications in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.11.011
Abstract: Mitochondrial dysfunction is known to be associated with neurodegenerative diseases (NDDs), which is a major burden on the society. Therefore, understanding the regulation of mitochondrial dysfunctions and its implication in neurodegeneration has been major goal… read more here.
Keywords: mitohormesis; neurodegenerative diseases; implications neurodegenerative; neurodegeneration ... See more keywords
Potential implications of polyphenolic compounds in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2155106
Abstract: Neurodegenerative diseases are common chronic diseases related to progressive damage to the nervous system. Current neurodegenerative diseases present difficulties and despite extensive research efforts to develop new disease-modifying therapies, there is still no effective treatment… read more here.
Keywords: disease; compounds neurodegenerative; potential implications; neurodegenerative diseases ... See more keywords
Adapting to the Pandemic: Experiences of Latin American Restaurants During COVID-19 and Potential Implications for Community Health and Food Environments
Sign Up to like & getrecommendations! Published in 2021 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzab029_026
Abstract: Abstract Objectives Assess how Latin American restaurants (LAR) have been adapting in response to COVID-19, and the potential implications of those changes for community food environments. Methods Qualitative study design using semi-structured interviews with LAR… read more here.
Keywords: community; covid potential; health; potential implications ... See more keywords
Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13037
Abstract: Resveratrol is a naturally occurring antioxidant with therapeutic potential in prevention and treatment of neoplastic disease and other human disorders. However, net clearance of resveratrol in humans is very high, mainly due to glucuronide conjugation.… read more here.
Keywords: resveratrol; vitro potential; resveratrol glucuronidation; probenecid ... See more keywords
Potential implications of SARS-CoV-2 epidemic in Africa: where are we going from now?
Sign Up to like & getrecommendations! Published in 2020 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-05147-8
Abstract: The SARS-CoV-2, which emerged from East Asia in December 2019, has rapidly evolved into a global pandemic infecting close to 7 million people. The current uncertainties regarding its impact on Africa calls for critical monitoring… read more here.
Keywords: implications sars; cov epidemic; sars cov; potential implications ... See more keywords
Recent advances in the pathophysiology of arterial hypertension: potential implications for clinical practice.
Sign Up to like & getrecommendations! Published in 2017 at "Polish archives of internal medicine"
DOI: 10.20452/pamw.3971
Abstract: Hypertension remains a major and growing public health problem associated with the greatest global rate of cardiovascular morbidity and mortality. Although numerous factors contribute to poor control of blood pressure (BP) and to pseudoresistance (eg,… read more here.
Keywords: arterial hypertension; advances pathophysiology; recent advances; pathophysiology arterial ... See more keywords
Lymphoid stromal cells - potential implications for the pathogenesis of CVID
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1122905
Abstract: Non-hematopoietic lymphoid stromal cells (LSC) maintain lymph node architecture and form niches allowing the migration, activation, and survival of immune cells. Depending on their localization in the lymph node, these cells display heterogeneous properties and… read more here.
Keywords: cell; stromal cells; cvid; potential implications ... See more keywords
miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810242
Abstract: T-cell immunoglobulin and mucin domain 1 (TIM-1) has been recently identified as one of the factors involved in the internalization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cells, in addition to… read more here.
Keywords: endothelial cells; 142 targets; potential implications; targets tim ... See more keywords
Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Immune Network"
DOI: 10.4110/in.2019.19.e4
Abstract: Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play… read more here.
Keywords: long noncoding; implications long; autoimmune diseases; rnas autoimmune ... See more keywords