Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration
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DOI: 10.1097/brs.0000000000001982
Abstract: Study Design. Laboratory study. Objective. To elucidate the potential involvement of the interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducers and activator of transcription (STAT3) pathway in the development of intervertebral disc (IVD) degeneration. Summary of Background Data.… read more here.
Keywords: stat3 pathway; potential involvement; ivd; jak stat3 ... See more keywords
Nicotinamide N-methyltransferase: potential involvement in cutaneous malignant melanoma
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DOI: 10.1097/cmr.0000000000000430
Abstract: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism. Data on literature have evidenced a possible role of NNMT in many solid cancers,… read more here.
Keywords: melanoma; methyltransferase potential; potential involvement; involvement cutaneous ... See more keywords
Potential involvement of circulating extracellular vesicles and particles on exercise effects in malignancies
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DOI: 10.3389/fendo.2023.1121390
Abstract: Physical activity and exercise have been widely related to prevention, treatment, and control for several non-communicable diseases. In this context, there are innumerous pre-clinical and clinical evidence indicating the potential role of exercise, beyond cancer… read more here.
Keywords: exercise effects; circulating evps; potential involvement; circulating extracellular ... See more keywords
Skeletal Muscle and COVID-19: The Potential Involvement of Bioactive Sphingolipids
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DOI: 10.3390/biomedicines10051068
Abstract: SARS-CoV-2 virus infection is the cause of the coronavirus disease 2019 (COVID-19), which is still spreading over the world. The manifestation of this disease can range from mild to severe and can be limited in… read more here.
Keywords: infection; muscle; potential involvement; skeletal muscle ... See more keywords
The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
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DOI: 10.3390/ijms22157944
Abstract: A presynaptic active zone organizer protein Bassoon orchestrates numerous important functions at the presynaptic active zone. We previously showed that the absence of Bassoon exclusively in forebrain glutamatergic presynapses (BsnEmx1cKO) in mice leads to developmental… read more here.
Keywords: protein bassoon; potential involvement; bsnemx1cko mice; bassoon ... See more keywords