Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL‐17 axis by activating PPARγ
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7546
Abstract: Psoriasis (PSO), an immune‐mediated chronic inflammatory skin disease, has seriously affected the quality of patients' life. It is urgent to find effective medicines with lower costs and less side effects. Baicalin (HQG) is the main… read more here.
Keywords: hqg; pharmacology; wnt signaling; potential mechanism ... See more keywords
Electrophysiologic Studies on the Risks and Potential Mechanism Underlying the Proarrhythmic Nature of Azithromycin
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-017-9401-7
Abstract: Abstract The mechanisms underlying arrhythmia induced by the clinical use of azithromycin are poorly understood. We aimed to investigate the proarrhythmic effects of azithromycin using electrocardiogram (ECG) and ion channel models. In vivo and in… read more here.
Keywords: guinea pig; times crc; electrophysiologic studies; potential mechanism ... See more keywords
The potential mechanism of postoperative cognitive dysfunction in older people
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.110791
Abstract: Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which seriously threatens the quality of patients' life, especially the older people. Accumulating attention has been paid to POCD worldwide in pace with the popularization… read more here.
Keywords: older people; mechanism; postoperative cognitive; cognitive dysfunction ... See more keywords
Degradation of lubricin by cathepsin G: a potential mechanism for lubricin degradation in osteoarthritis patients' synovial fluid
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and Cartilage"
DOI: 10.1016/j.joca.2018.02.417
Abstract: Degradation Of Lubricin By Cathepsin G : A Potential Mechanism For Lubricin Degradation In Osteoarthritis Patients' Synovial Fluid read more here.
Keywords: degradation; degradation lubricin; osteoarthritis; lubricin cathepsin ... See more keywords
Effects of Danshen tablets on pharmacokinetics of atorvastatin calcium in rats and its potential mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2018.1424209
Abstract: Abstract Context: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in the clinic. Objective: This study investigated the effects of DST on… read more here.
Keywords: dst; danshen tablets; atorvastatin calcium; potential mechanism ... See more keywords
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2087688
Abstract: Abstract Context Ginkgo leaf tablet (GLT), a traditional Chinese herbal formula, is often combined with rosiglitazone (ROS) for type 2 diabetes mellitus treatment. However, the drug-drug interaction between GLT and ROS remains unknown. Objective To… read more here.
Keywords: leaf tablet; dose glt; multiple dose; ginkgo leaf ... See more keywords
Potential mechanism of SARS‐CoV‐2‐associated central and peripheral nervous system impairment
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.13657
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is more than merely a respiratory disease, as it also presents with various neurological symptoms. SARS‐CoV‐2 may infect the central nervous system (CNS) and thus is neurotropic. However,… read more here.
Keywords: cov associated; mechanism; potential mechanism; nervous system ... See more keywords
Targets and Potential Mechanism of Scutellaria baicalensis in Treatment of Primary Hepatocellular Carcinoma Based on Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/8762717
Abstract: Objective To analyze the target and potential mechanism of Scutellaria baicalensis (SB) in the treatment of HCC based on bioinformatics, so as to provide suggestions for the diagnosis, treatment, and drug development of hepatocellular carcinoma… read more here.
Keywords: hcc; analysis; potential mechanism; treatment ... See more keywords
A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregases in Liquid Droplets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.854380
Abstract: Insoluble protein deposits are hallmarks of neurodegenerative disorders and common forms of dementia. The aberrant aggregation of misfolded proteins involves a complex cascade of events that occur over time, from the cellular to the clinical… read more here.
Keywords: aggregates proteasomes; liquid droplets; targeting aggregates; potential mechanism ... See more keywords
Network Pharmacology and Molecular Docking to Elucidate the Potential Mechanism of Ligusticum Chuanxiong Against Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.854215
Abstract: Background: Osteoarthritis (OA) is a degenerative disease which serious affects patients. Ligusticum chuanxiong (CX) has been shown to have a certain curative effect on osteoarthritis in traditional Chinese medicine therapy. This study is based on… read more here.
Keywords: molecular docking; network; pharmacology; osteoarthritis ... See more keywords
Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113307
Abstract: Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation”. This news has… read more here.
Keywords: evasion potential; mechanism; immune evasion; negative immune ... See more keywords