Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104895
Abstract: A series of 4-aminoalkyl-1(2H)-phthalazinone derivatives was designed and synthesized as potential multifunctional agents for Alzheimer's disease (AD) treatment. In vitro biological assay results demonstrated that most synthesized compounds exhibited significant AChE inhibition, moderate to high… read more here.
Keywords: design synthesis; alzheimer disease; potential multifunctional; vitro evaluation ... See more keywords
Chalcone Derivatives with a High Potential as Multifunctional Antioxidant Neuroprotectors
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05518
Abstract: A systematic, rational search for chalcone derivatives with multifunctional behavior has been carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 derivatives were constructed by incorporating functional groups into the… read more here.
Keywords: chalcone derivatives; potential multifunctional; derivatives high; high potential ... See more keywords
An ionic liquid as a potential multifunctional lubricating oil additive
Sign Up to like & getrecommendations! Published in 2018 at "Petroleum Science and Technology"
DOI: 10.1080/10916466.2018.1519574
Abstract: Abstract Homopolymer of decyl acrylate was synthesized and blended with phosphonium based ionic liquid and their characterisation was carried out by spectral method (NMR, IR), thermogravimetric analysis and gel permeation chromatography (GPC). Performance of these… read more here.
Keywords: ionic liquid; lubricating oil; potential multifunctional; liquid potential ... See more keywords
Therapeutic Potential of Multifunctional Tacrine Analogues
Sign Up to like & getrecommendations! Published in 2019 at "Current Neuropharmacology"
DOI: 10.2174/1570159x16666180412091908
Abstract: Abstract: Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in… read more here.
Keywords: therapeutic potential; tacrine analogues; tacrine; alzheimer disease ... See more keywords
Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota
Sign Up to like & getrecommendations! Published in 2023 at "Materials"
DOI: 10.3390/ma16020699
Abstract: Neurological diseases remain a major concern due to the high world mortality rate and the absence of appropriate therapies to cross the blood–brain barrier (BBB). Therefore, the major focus is on the development of such… read more here.
Keywords: potential multifunctional; latent potential; role; neurological diseases ... See more keywords