Advances in IKBKE as a potential target for cancer therapy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2678
Abstract: IKBKE (inhibitor of nuclear factor kappa‐B kinase subunit epsilon), a member of the nonclassical IKK family, plays an important role in the regulation of inflammatory reactions, activation and proliferation of immune cells, and metabolic diseases.… read more here.
Keywords: potential target; ikbke potential; advances ikbke; target ... See more keywords
Purinergic system as a potential target for inflammation and toxicity induced by thymol in immune cells and tissues
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3416-7
Abstract: Thymol is a phytochemical component present in many plants used as food additive in order to promote animal growth due to its several biological properties. However, possible side effects of thymol remain poorly known limited… read more here.
Keywords: potential target; toxicity induced; toxicity; inflammation toxicity ... See more keywords
circRNA is a potential target for cardiovascular diseases treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04286-z
Abstract: Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized by their covalently closed-loop structures without a 5' cap or a 3' poly(A) tail. With the evolution of high-throughput sequencing technology and bioinformatics,… read more here.
Keywords: potential target; biochemistry; target cardiovascular; cardiovascular diseases ... See more keywords
C-MET as a potential target therapy toward personalized therapy in some pediatric tumors: An overview.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.08.007
Abstract: Althoughpediatric tumors represent less than 1% of all new cancer diagnoses, they still rank the second in the list of disease-related morbidity and mortality in children in the US. Combining biomarker-driven targeted therapy with individualized… read more here.
Keywords: potential target; met potential; target therapy; pediatric tumors ... See more keywords
MITOCHONDRIAL HEAT SHOCK PROTEIN MORTALIN AS POTENTIAL TARGET FOR THERAPIES BASED ON OXIDATIVE STRESS.
Sign Up to like & getrecommendations! Published in 2021 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2021.102256
Abstract: BACKGROUND Treatments based on production of reactive oxygen species for bladder cancer such as photodynamic therapy (PDT) have been marginalized due to low specificity and the existence of resistance mainly associated with the up-regulation of… read more here.
Keywords: heat shock; potential target; stress; oxidative stress ... See more keywords
Melatonin is a potential target for improving horticultural crop resistance to abiotic stress
Sign Up to like & getrecommendations! Published in 2022 at "Scientia Horticulturae"
DOI: 10.1016/j.scienta.2021.110560
Abstract: Abstract Crop yield and quality are greatly affected by abiotic stresses, such as salinity, high and low temperature, drought and heavy metals, which pose major threat to human survival and development. Melatonin (N-acetyl-5-methoxytryptamine), an indoleamine… read more here.
Keywords: potential target; stress; melatonin potential; melatonin ... See more keywords
In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer's Disease Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04520
Abstract: Alterations in formaldehyde (FA) homeostasis are associated with the pathology of Alzheimer's disease (AD). In vivo tracking of FA flux is important for understanding the underlying molecular mechanisms, but is challenging due to the lack… read more here.
Keywords: live mice; mice; potential target; pathology ... See more keywords
Identification of Enolase 1 as a Potential Target for Magnaporthe oryzae: Integrated Proteomic and Molecular Dynamics Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01265
Abstract: Rice blast is an essential factor affecting rice yield and quality, which is caused by Magnaporthe oryzae (M. oryzae). Isobavachalcone (IBC) is a botanical fungicide derived from the seed extract of the Leguminosae plant Psoralea… read more here.
Keywords: oryzae; molecular dynamics; magnaporthe oryzae; dynamics simulation ... See more keywords
Stretching Peptides’ Potential to Target Protein–Protein Interactions
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00364
Abstract: Protein−protein interactions (PPIs) are key biological targets for next-generation drug discovery. Peptide-derived molecules are ideal for targeting PPIs because they can closely mimic the binding surfaces presented by the proteins in the PPI. Conformational control… read more here.
Keywords: protein protein; peptides potential; stretching peptides; protein interactions ... See more keywords
Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41589
Abstract: Beyond classical motor symptoms, motivational and affective deficits are frequently observed in Parkinson’s disease (PD), dramatically impairing the quality of life of patients. Using bilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta (SNc)… read more here.
Keywords: potential target; implication; neuropsychiatric symptoms; parkinson disease ... See more keywords
CCNE1 is a potential target of Metformin for tumor suppression of ovarian high-grade serous carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2109362
Abstract: ABSTRACT High-grade serous ovarian cancer (HGSOC) is the most common and malignant type of ovarian cancer, accounting for 70%–80% of mortality. However, the treatment of HGSOC has improved little in the past few decades. Metformin… read more here.
Keywords: target metformin; hgsoc; ccne1; treatment ... See more keywords