The Potential of Targeting P53 and HSP90 Overcoming Acquired MAPKi-Resistant Melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-019-0622-9
Abstract: Opinion StatementMelanoma is the deadliest form of skin cancer worldwide. The rising melanoma incidence and mortality, along with its high propensity for metastasis highlights the urgency to identify more effective therapeutic targets. Approximately, one half… read more here.
Keywords: melanoma; targeting p53; acquired mapki; p53 hsp90 ... See more keywords
The potential of targeting Sin3B and its associated complexes for cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1386655
Abstract: ABSTRACT Introduction: Sin3B serves as a scaffold for chromatin-modifying complexes that repress gene transcription to regulate distinct biological processes. Sin3B-containing complexes are critical for cell cycle withdrawal, and abrogation of Sin3B-dependent cell cycle exit impacts… read more here.
Keywords: sin3b containing; containing complexes; sin3b; targeting sin3b ... See more keywords
Potential targeting of B7‐H4 for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12530
Abstract: Observations noting the presence of white blood cell infiltrates within tumors date back more than a century, however the cellular and molecular mechanisms regulating tumor immunity continue to be elucidated. The recent successful use of… read more here.
Keywords: treatment cancer; cancer; potential targeting; cancer potential ... See more keywords
The therapeutic potential of targeting ACE2 in COVID-19.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202009_23067
Abstract: OBJECTIVE ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic SARS-CoV-2. This mini-review explores the potential of targeting ACE2 in blocking viral penetrance. MATERIALS AND METHODS PubMed search was conducted… read more here.
Keywords: ace2 covid; targeting ace2; ace2; receptor ... See more keywords
The Therapeutic Potential for Targeting Group 2 Innate Lymphoid Cells in Asthma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.930862
Abstract: T helper type 2 cells (Th2 cells) and group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are activated by epithelial-derived cytokines [interleukin-25 (IL-25),… read more here.
Keywords: potential targeting; therapeutic potential; innate lymphoid; group innate ... See more keywords
Therapeutic Potential of Targeting ß-Arrestin
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00124
Abstract: ß-arrestins are multifunctional proteins that modulate heptahelical 7 transmembrane receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors that regulate most physiological processes. ß-arrestin modulation of GPCR function includes termination of G… read more here.
Keywords: protein; signaling pathway; targeting arrestin; therapeutic potential ... See more keywords