Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203291
Abstract: Due to the continuous rise in biofilm‐related infections, biofilms seriously threaten human health. The formation of biofilms makes conventional antibiotics ineffective and dampens immune clearance. Therefore, it is important to understand the mechanisms of biofilm… read more here.
Keywords: potential targets; prevention treatment; biofilms; formation ... See more keywords
Lithium in Environment and Potential Targets to Reduce Lithium Toxicity in Plants
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-019-09957-2
Abstract: Industrialization and inevitable mining have resulted in the release of some metals in environment, which have different uses on the one hand and also showed environmental toxicity. Lithium (Li) is one of them; however, its… read more here.
Keywords: potential targets; toxicity; lithium environment; targets reduce ... See more keywords
α2A- and α2C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1004-1
Abstract: The poor norepinephrine innervation and high density of Gi/o-coupled α2A- and α2C-adrenoceptors in the striatum and the dense striatal dopamine innervation have prompted the possibility that dopamine could be an effective adrenoceptor ligand. Nevertheless, the… read more here.
Keywords: adrenoceptors potential; potential targets; dopamine receptor; receptor ligands ... See more keywords
mGlu receptors as potential targets for novel antidepressants
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2018.02.001
Abstract: HighlightsmGlu2/3 antagonists exert ketamine‐like antidepressant effects in rodent models.mGlu2/3 antagonists shared some of their mechanisms with ketamine.mGlu5 NAMs exert antidepressant effects in rodent models.The mechanisms of mGlu5 NAMs may differ from those of ketamine.Antidepressant potential… read more here.
Keywords: novel antidepressants; mglu receptors; potential targets; receptor ... See more keywords
A Clinical and Animal Experiment Integrated Platform for Small-Molecule Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the Therapeutic Efficacy of Yinchenhao Tang for Jaundice Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Engineering"
DOI: 10.1016/j.eng.2020.12.016
Abstract: Abstract A herbal prescription in traditional Chinese medicine (TCM) has great complexity, with multiple components and multiple targets, making it extremely challenging to determine its bioactive compounds. Yinchenhao Tang (YCHT) has been extensively used for… read more here.
Keywords: yinchenhao tang; herbal prescription; potential targets; clinical animal ... See more keywords
Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis–Lycium barbarum coupled-herbs against oligoasthenozoospermia
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80780-6
Abstract: Oligoasthenozoospermia (OA) is one of the most common types of male infertility affecting sperm count and sperm motility. Unfortunately, it is difficult for existing drugs to fundamentally improve the sperm quality of OA patients, because… read more here.
Keywords: morinda officinalis; potential targets; pharmacology; officinalis lycium ... See more keywords
Beyond JAK-2: potential targets for myeloproliferative neoplasm therapy
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1450628
Abstract: ABSTRACT Introduction: The outlook for patients with myeloproliferative neoplasms, particularly myelofibrosis, has improved in recent years, with greater understanding of the pathogenesis and the subsequent development of a plethora of new agents. Areas covered: This… read more here.
Keywords: myeloproliferative neoplasm; beyond jak; potential targets; jak potential ... See more keywords
Potential targets for next generation antimicrobial glycoconjugate vaccines
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuy011
Abstract: Abstract Cell surface carbohydrates have been proven optimal targets for vaccine development. Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune response to the glycan moiety. Licensed glycoconjugate vaccines are produced by chemical… read more here.
Keywords: targets next; generation antimicrobial; potential targets; glycoconjugate vaccines ... See more keywords
TargetScore used to reveal potential targets of miRNA203 and miRNA-146a in psoriasis by integrating microRNA overexpression and microarray data
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000012671
Abstract: Objective: Systematic tracking of microRNA (miRNA) targets remains a challenge. In our work, we aimed to use TargetScore to investigate the potential targets of miRNA203 and miRNA-146a in psoriasis by integrating miRNA overexpression information and… read more here.
Keywords: 146a psoriasis; mirna 203; mirna203 mirna; potential targets ... See more keywords
Comparative proteomic analysis provides insight into the key proteins as potential targets underlying the effect of malachite green against Ichthyophthirius multifiliis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of fish diseases"
DOI: 10.1111/jfd.13346
Abstract: Target identification is important for drug discovery. Unfortunately, no drug targets have been found in Ichthyophthirius multifiliis until now and further limited development of the novel drug for Ichthyophthiriasis. In this study, an iTRAQ-based quantitative… read more here.
Keywords: malachite green; potential targets; proteomic analysis; ichthyophthirius multifiliis ... See more keywords
Computation-Based Discovery of Potential Targets for Rheumatoid Arthritis and Related Molecular Screening and Mechanism Analysis of Traditional Chinese Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1905077
Abstract: This study is aimed at screening potential therapeutic ingredients in traditional Chinese medicine (TCM) and identifying the key rheumatoid arthritis (RA) targets using computational simulations. Data for TCM-active ingredients with clear pharmacological effects were collected.… read more here.
Keywords: potential targets; rheumatoid arthritis; chinese medicine; analysis ... See more keywords