Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23693
Abstract: Astrocytes are the most widespread and heterogeneous glial cells in the central nervous system and key regulators for brain development. They are capable of receiving neurotransmitters produced by synaptic activities and regulating synaptic functions by… read more here.
Keywords: therapeutic strategy; neurodegenerative diseases; potential therapeutic; optogenetic manipulation ... See more keywords
POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.194_2631
Abstract: (5) RNA-seq. The abundance of gene transcriptswas determined by RNA sequencing, using the Illumina HiSeq 2500 platform. (6) Proteomic studies were performed using data independent analysis (DIA) Liquid chromatography–mass spectrometry (LC/MS). (7) Data analysis. Omics… read more here.
Keywords: duvelisib mantle; analysis; therapeutic advantage; mantle cell ... See more keywords
Malic enzyme 2 as a potential therapeutic drug target for cancer
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1930
Abstract: Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the “hallmarks of cancer.” The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular… read more here.
Keywords: enzyme potential; malic enzyme; target; therapeutic drug ... See more keywords
Potential therapeutic effects of curcumin in gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27229
Abstract: Despite recent advancements in understanding of the biology of gastric cancer, treatment of patients with advanced gastric cancer remains a major problem. Among different type of phytochemicals, curcumin, a welltable ‐known phytochemical, has been shown… read more here.
Keywords: gastric cancer; effects curcumin; curcumin gastric; therapeutic effects ... See more keywords
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21965
Abstract: The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered the critical risk factors for developing vascular dysfunctions… read more here.
Keywords: options management; drugs potential; therapeutic options; potential therapeutic ... See more keywords
In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9670-4_15
Abstract: The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro model that is capturing liver… read more here.
Keywords: hepatotoxicity potential; vitro assessment; assessment hepatotoxicity; biology ... See more keywords
Ficellomycin: an aziridine alkaloid antibiotic with potential therapeutic capacity
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-8934-4
Abstract: Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus, which displays high in vitro activity against Gram-positive bacteria including multidrug resistant strains of Staphylococcus aureus. Compared to currently available antibiotics, ficellomycin exhibits a unique mechanism… read more here.
Keywords: aziridine alkaloid; alkaloid antibiotic; therapeutic capacity; ficellomycin aziridine ... See more keywords
Assessment of the potential therapeutic effects of omeprazole in Schistosoma mansoni infected mice
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06465-w
Abstract: Schistosomiasis is a neglected chronic parasitic disease with a significant lasting morbidity. Currently, praziquantel (PZQ) is the most efficient drug for schistosomiasis worldwide. However, the possibility of the occurrence of resistance to PZQ is increasing.… read more here.
Keywords: mansoni; effects omeprazole; therapeutic effects; potential therapeutic ... See more keywords
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09776-9
Abstract: The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular functions. It is most commonly expressed on immune cells and is highly upregulated in a… read more here.
Keywords: gated p2x7; cancer; potential therapeutic; receptor ... See more keywords
Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8938-7
Abstract: The host response to either exogenous or endogenous insults produces a series of changes, characterized by alterations in immunological functions and generation of mediators called cytokines which include the interleukin-1 (IL-1) family members. IL-1 acts… read more here.
Keywords: innate; anti inflammatory; immunity; therapeutic use ... See more keywords
Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02082-2
Abstract: Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of effective treatment. Microglia are a major component of the innate immune system, and they respond to acute brain injury… read more here.
Keywords: inflammasome; intracerebral hemorrhage; neuroinflammation; therapeutic targets ... See more keywords