DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02050
Abstract: According to the World Health Organization (WHO), 422 million people are suffering from diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose control to prevent long-term diabetes complications. Unfortunately, current therapies have failed… read more here.
Keywords: therapeutics cell; cell proliferation; potential therapeutics; regeneration ... See more keywords
Hexahydropyrrolo[2,3-b]indole compounds as potential therapeutics for Alzheimer Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00297
Abstract: Alzheimer's disease (AD) is the most common form of dementia among the elderly and has become a leading public health concern worldwide. It represents a huge economic and psychological burden to caregivers and families. The… read more here.
Keywords: compounds potential; alzheimer disease; potential therapeutics; indole compounds ... See more keywords
Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230419102140
Abstract: Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk… read more here.
Keywords: diabetic wounds; diabetic wound; mmp; management diabetic ... See more keywords
Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life13010102
Abstract: Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability. There is no disease-modifying drug available for the treatment of OA.… read more here.
Keywords: compounds potential; natural compounds; cartilage; degradation ... See more keywords
Ursolic Acid Analogs as Potential Therapeutics for Cancer
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DOI: 10.3390/molecules27248981
Abstract: Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits and many traditional medicinal plants. It is a structural isomer of Oleanolic Acid. The medicinal application of UA has been… read more here.
Keywords: acid analogs; therapeutics cancer; ursolic acid; analogs potential ... See more keywords
Insights into Molecular Mechanisms Underlying COVID-19 Pathogenesis and Potential Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Indian Journal of Pharmaceutical Sciences"
DOI: 10.36468/pharmaceutical-sciences.839
Abstract: The coronavirus disease 2019 is a disease caused by severe acute respiratory syndrome coronavirus 2 and continues to pose a global threat resulting in thousands of deaths. In the absence of effective therapeutics, implementation of… read more here.
Keywords: potential therapeutics; disease; pathogenesis; coronavirus ... See more keywords