RIPK1 inhibition in malignant cells potentiates immunotherapy and radiotherapy outcome
Sign Up to like & getrecommendations! Published in 2024 at "Oncoimmunology"
DOI: 10.1080/2162402x.2024.2425465
Abstract: ABSTRACT Apoptosis, necroptosis and pro-inflammatory NF-κB-dependent signaling are repressed by receptor-interacting serine/threonine-protein kinase 1 (RIPK1). A recent paper in Immunity describes a small molecule inducing the proteolytic degradation of RIPK1. In preclinical experiments, this RIPK1… read more here.
Keywords: inhibition malignant; malignant cells; potentiates immunotherapy; radiotherapy ... See more keywords
Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aal4712
Abstract: Tumor lymphangiogenesis, a driver of immunosuppression and metastasis, also potentiates immunotherapy. Unintentional immunotherapy inhibition Metastatic spread depends on lymphangiogenesis, and mediators of this pathway are targeted clinically for cancer treatment. Fankhauser et al. used mouse… read more here.
Keywords: lymphangiogenesis; potentiates immunotherapy; vegf; tumor lymphangiogenesis ... See more keywords