Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22736
Abstract: Stress has a profound effect on ability to express neuronal plasticity, learning, and memory. Likewise, epileptic seizures lead to massive changes in brain connectivity, and in ability to undergo long term changes in reactivity to… read more here.
Keywords: long term; effect; stress; potentiation ... See more keywords
Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4126
Abstract: Hsp104, a yeast protein disaggregase, can be potentiated via numerous missense mutations at disparate locations throughout the coiled‐coil middle domain (MD). Potentiated Hsp104 variants can counter the toxicity and misfolding of TDP‐43, FUS, and α‐synuclein,… read more here.
Keywords: scanning mutagenesis; drivers hsp104; hsp104 potentiation; potentiation ... See more keywords
Potentiation of a neuronal nicotinic receptor via pseudo-agonist site
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2993-7
Abstract: Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)3(β2)2 and (α4)2(β2)3, each with distinct pharmacological signatures; (α4)3(β2)2 receptors are strongly potentiated by the drug NS9283, whereas (α4)2(β2)3 receptors are unaffected.… read more here.
Keywords: neuronal nicotinic; pseudo agonist; agonist site; receptor ... See more keywords
Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR1-Dependent Potentiation After Pentylenetetrazole-Induced Acute Seizures in Young Rats
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-00647-3
Abstract: The mechanisms of impairment in long-term potentiation after status epilepticus (SE) remain unclear. We investigated the properties of LTP induced by theta-burst stimulation in hippocampal slices of rats 3 h and 1, 3, and 7 days… read more here.
Keywords: long term; dependent ltp; mglur1 dependent; nmda dependent ... See more keywords
Short-Term Visual Experience Leads to Potentiation of Spontaneous Activity in Mouse Superior Colliculus.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience bulletin"
DOI: 10.1007/s12264-020-00622-3
Abstract: Spontaneous activity in the brain maintains an internal structured pattern that reflects the external environment, which is essential for processing information and developing perception and cognition. An essential prerequisite of spontaneous activity for perception is… read more here.
Keywords: visual experience; spontaneous activity; potentiation; activity ... See more keywords
NMDA receptor partial agonist, d-cycloserine, enhances 10 Hz rTMS-induced motor plasticity, suggesting long-term potentiation (LTP) as underlying mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.01.005
Abstract: While daily repetitive transcranial magnetic stimulation (rTMS) is FDA-approved to treat depression and obsessive-compulsive disorder, we are still unclear about its therapeutic mechanism of action. Better understanding of the fundamental mechanisms of rTMS-induced changes would… read more here.
Keywords: nmda receptor; rtms; rtms induced; motor ... See more keywords
Anticipatory representations of reward and threat in perceptual areas from preadolescence to late adolescence
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Cognitive Neuroscience"
DOI: 10.1016/j.dcn.2017.03.001
Abstract: This study examined whether changes in perceptual processes can partially account for the increase in reward-orientated behaviour during adolescence. This was investigated by examining reinforcement-dependent potentiation to discriminative stimuli (SD) that predicted rewarding or threatening… read more here.
Keywords: reinforcement dependent; dependent potentiation; adolescence; perceptual areas ... See more keywords
Ultra-resistant schizophrenia and potentiation strategies
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.1639
Abstract: Introduction Treatment resistance to clozapine is estimated at 40–70% of the treated population. Several clozapine potentiation strategies have come into clinical practice although often without evidence-based support. Objective The aim of our work was to… read more here.
Keywords: schizophrenia; resistant schizophrenia; ultra resistant; potentiation strategies ... See more keywords
Differential Age-dependent Mechanisms of High-frequency Stimulation-induced Potentiation in the Prefrontal Cortex–Basolateral Amygdala Pathway Following Fear Extinction
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2022.04.004
Abstract: Post-weaning is a critical period for brain maturation in the rat and is comparable to childhood and adolescences in humans. The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) are two brain regions that… read more here.
Keywords: fear extinction; prefrontal cortex; adult; potentiation ... See more keywords
Differential involvement of Ca2+/calmodulin-dependent protein kinases and mitogen-activated protein kinases in the dopamine D1/D5 receptor-mediated potentiation in hippocampal CA1 pyramidal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2016.07.020
Abstract: HighlightsD1/D5 receptor‐dependent LTP (DA‐LTP) in CA1 region is MEK/MAPK pathway dependent.Here we studied the differential role of CaMKs and MEKs during DA‐LTP.With weak dopaminergic activation, both CaMKII and MEKs were necessary for DA‐LTP.During stronger dopaminergic… read more here.
Keywords: potentiation; protein kinases; activation; hippocampal ca1 ... See more keywords
Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.172856
Abstract: Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews… read more here.
Keywords: long term; ketamine; response ketamine; antidepressant response ... See more keywords