Germline variation in the 3′‐untranslated region of the POU2AF1 gene is associated with susceptibility to lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22652
Abstract: Genetic variations in certain genes may alter the susceptibility to lymphoma. We searched electronic databases and selected candidate single‐nucleotide polymorphisms (SNPs) located within 3′‐untranslated regions (3′‐UTRs) that might affect miRNA‐binding ability in the 50 most… read more here.
Keywords: lymphoma; susceptibility lymphoma; pou2af1; lymphoma 001 ... See more keywords
POU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1990822
Abstract: Abdominal aortic aneurysm (AAA) is life-threatening, its natural course is progressively sac expansion and rupture. Elegant studies have been conducted to investigate the molecular markers associated with AAA growth and expansion, this topic however, still… read more here.
Keywords: large aaa; pou2af1; analysis; aortic aneurysm ... See more keywords
OCA‐B does not act as a transcriptional coactivator in T cells
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12543
Abstract: Pou2af1 encodes for OCA‐B, a coactivator of OCT‐1/2 transcription factors, which plays a key role in B‐cell maturation. The function of OCA‐B has also been studied in T cells, where T cells from Pou2af1−/− mice… read more here.
Keywords: cell; pou2af1; coactivator cells; transcriptional coactivator ... See more keywords
POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-142580
Abstract: Background: Functional genomics studies based on CRISPR and shRNA have documented that multiple myeloma (MM) cells are preferentially dependent (compared to other neoplasias) on a series of TFs, including IKZF1 and IKZF3 (which are targeted… read more here.
Keywords: pou2af1; cell; activation; research funding ... See more keywords