Tick-Borne Flaviviruses, with a Focus on Powassan Virus
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00106-17
Abstract: The tick-borne pathogen Powassan virus is a rare cause of encephalitis in North America and the Russian Far East. The number of documented cases described since the discovery of Powassan virus in 1958 may be read more here.
Keywords: tick borne; borne flaviviruses; virus; powassan virus ... See more keywords
A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008788
Abstract: Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the family Flaviviridae. POWV causes severe neurological sequalae, meningitis, encephalitis,… read more here.
Keywords: novel synthetic; synthetic dna; powv sev; powv ... See more keywords
A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010573
Abstract: Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen… read more here.
Keywords: domain iii; nanoparticle immunogen; powv; powassan virus ... See more keywords
Powassan Virus Lineage I in Field-Collected Dermacentor variabilis Ticks, New York, USA
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DOI: 10.3201/eid2902.220410
Abstract: Powassan virus is a tickborne flavivirus that can cause lethal or debilitating neurologic illness. It is canonically transmitted by Ixodes spp. ticks but might spill over to sympatric Dermacentor species. We detected Powassan virus lineage… read more here.
Keywords: field collected; new york; ticks new; virus lineage ... See more keywords
Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA
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DOI: 10.3201/eid2904.221005
Abstract: We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM and plaque reduction neutralization assays.… read more here.
Keywords: powassan virus; next generation; metagenomic next; ohio usa ... See more keywords
Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo
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DOI: 10.3390/pathogens11101218
Abstract: Powassan virus (POWV) is a tick-borne flavivirus (TBFV) that can cause severe encephalitis in humans with a case–fatality rate as high as 11%. Patients who survive severe encephalitic disease can develop long-term neurological sequelae that… read more here.
Keywords: induces structural; powassan virus; structural changes; virus induces ... See more keywords
Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-Coding RNAs
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DOI: 10.3390/v12020190
Abstract: Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence suggesting that their… read more here.
Keywords: murray valley; non coding; terminal regions; valley encephalitis ... See more keywords
Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11030612
Abstract: Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we… read more here.
Keywords: disease; live attenuated; powv; powassan virus ... See more keywords