Using Filters to Estimate Regional Lung Deposition with Dry Powder Inhalers.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03082-0
Abstract: PURPOSE To develop an in vitro method to rapidly evaluate regional lung doses delivered by pharmaceutical inhalers. Currently, cascade impactor measurements are used, but these are resource intensive and require significant post processing of in… read more here.
Keywords: regional lung; dry powder; estimate regional; regional deposition ... See more keywords
In-vitro and Particle Image Velocimetry Studies of Dry Powder Inhalers.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119966
Abstract: Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and… read more here.
Keywords: particle image; dry powder; image velocimetry; vitro particle ... See more keywords
Streptomycin sulfate dry powder inhalers for the new tuberculosis treatment schedule
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.05.052
Abstract: Abstract This study was conducted regarding the potentials of the carrier-mediated pulmonary delivery in treatment of the Tuberculosis (TB). Bovine Serum Albumin (BSA) Nanoparticles (NPs) containing streptomycin sulfate (STP) were prepared by High-Pressure Homogenization (HPH).… read more here.
Keywords: streptomycin sulfate; dry powder; treatment; tuberculosis ... See more keywords
Coupled CFD-DEM model for dry powder inhalers simulation: Validation and sensitivity analysis for the main model parameters
Sign Up to like & getrecommendations! Published in 2021 at "Powder Technology"
DOI: 10.1016/j.powtec.2021.02.044
Abstract: Abstract The use of computational techniques in the design of dry powder inhalers (DPI), as well as in unravelling the complex mechanisms of drug aerosolization, has increased significantly in recent years. Computational fluid dynamics (CFD)… read more here.
Keywords: dry powder; model; powder; coupled cfd ... See more keywords
Combining experimental and computational techniques to understand and improve dry powder inhalers
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2026922
Abstract: ABSTRACT Introduction Dry Powder Inhalers (DPIs) continue to be developed to deliver an expanding range of drugs to treat an ever-increasing range of medical conditions; with each drug and device combination needing a specifically designed… read more here.
Keywords: experimental computational; powder inhalers; dry powder; combining experimental ... See more keywords
Dry powder inhalation, part 1: ancient history and precursors to modern dry powder inhalers
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2112568
Abstract: ABSTRACT Introduction Inhalation of herbs and other compounds has a long history but habits for medical treatment are intertwined with rituals to obtain hallucinatory effects and pleasurable sensations. Several examples of inhaled herbs, and the… read more here.
Keywords: history; powder inhalers; dry powder; powder inhalation ... See more keywords
Dry Powder Inhalers for Proteins Using Cryo-Milled Electrospun Polyvinyl Alcohol Nanofiber Mats
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165158
Abstract: To enable the efficient delivery of drugs to the lungs, the drug particle design for most dry powder inhalers (DPIs) involves reducing the aerodynamic particle size to a few microns using methods such as spray-drying… read more here.
Keywords: nanofiber mats; powder inhalers; dry powder; cryo milled ... See more keywords
Experimental Evaluation of Dry Powder Inhalers during Inhalation and Exhalation Using a Model of the Human Respiratory System (xPULM™)
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030500
Abstract: Dry powder inhalers are used by a large number of patients worldwide to treat respiratory diseases. The objective of this work is to experimentally investigate changes in aerosol particle diameter and particle number concentration of… read more here.
Keywords: respiratory system; powder inhalers; dry powder; model ... See more keywords
State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
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DOI: 10.3390/pharmaceutics14061185
Abstract: Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring… read more here.
Keywords: powder inhalers; dry powder; formulation; spray dried ... See more keywords
Development of an Add-On Device Using 3D Printing for the Enhancement of Drug Administration Efficiency of Dry Powder Inhalers (Accuhaler)
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091922
Abstract: The goal of this study was to develop an add-on device for dry powder inhalers (Accuhaler) via 3D printing to improve drug administration efficiency in patients with limited inspiratory capacity, including young children, the elderly,… read more here.
Keywords: dry powder; powder inhalers; add device; device ... See more keywords