Modeling Powassan virus infection in Peromyscus leucopus, a natural host
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005346
Abstract: The tick-borne flavivirus, Powassan virus (POWV) causes life-threatening encephalitis in humans in North America and Europe. POWV is transmitted by ixodid tick vectors that feed on small to medium-sized mammals, such as Peromyscus leucopus mice,… read more here.
Keywords: peromyscus leucopus; infection; mice; powv ... See more keywords
A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008788
Abstract: Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the family Flaviviridae. POWV causes severe neurological sequalae, meningitis, encephalitis,… read more here.
Keywords: novel synthetic; synthetic dna; powv sev; powv ... See more keywords
A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010573
Abstract: Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen… read more here.
Keywords: domain iii; nanoparticle immunogen; powv; powassan virus ... See more keywords
Horizontal and Vertical Transmission of Powassan Virus by the Invasive Asian Longhorned Tick, Haemaphysalis longicornis, Under Laboratory Conditions
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DOI: 10.3389/fcimb.2022.923914
Abstract: The Asian longhorned tick, Haemaphysalis longicornis, is an ixodid tick native to East Asia that was first detected in North America outside a port of entry in 2017. This invasive species has since been detected… read more here.
Keywords: transmission; powv; longicornis; asian longhorned ... See more keywords
Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11030612
Abstract: Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we… read more here.
Keywords: disease; live attenuated; powv; powassan virus ... See more keywords