Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800541
Abstract: Protein phosphatase‐1 (PP1)‐disrupting peptides (PDPs) are selective chemical modulators of PP1 that liberate the active PP1 catalytic subunit from regulatory proteins; thus allowing the dephosphorylation of nearby substrates. We have optimized the original cell‐active PDP3… read more here.
Keywords: pp1 activity; interrogating pp1; pp1 disrupting; disrupting peptides ... See more keywords
Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C‐Terminal Phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000669
Abstract: Phosphoprotein phosphatase‐1 (PP1) is a key player in the regulation of phospho‐serine (pSer) and phospho‐threonine (pThr) dephosphorylation and is involved in a large fraction of cellular signaling pathways. Aberrant activity of PP1 has been linked… read more here.
Keywords: protein; towards dissecting; phosphatase; mechanism ... See more keywords
Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0635-0
Abstract: Protein phosphatase 1 (PP1) is a key regulator of important cardiac signaling pathways. Dysregulation of PP1 has been heavily implicated in cardiac dysfunctions. Accordingly, pharmacological targeting of PP1 activity is considered for therapeutic intervention in… read more here.
Keywords: pp1 isoforms; heart; pp1; phosphatase pp1 ... See more keywords
Complex functionality of protein phosphatase 1 isoforms in the heart.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110059
Abstract: Protein phosphatase 1(PP1) is a key regulator of cardiac function through dephosphorylating serine/threonine residues within target proteins to oppose the function of protein kinases. Studies from failing hearts of animal models and human patients have… read more here.
Keywords: protein; complex functionality; heart; pp1 ... See more keywords
PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.060
Abstract: Apical-basal polarity is a common trait that underlies epithelial function. Although the asymmetric distribution of cortical polarity proteins works in a functioning equilibrium, it also retains plasticity to accommodate cell division, during which the basolateral… read more here.
Keywords: apical basal; basal polarity; pp1; lgl ... See more keywords
Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01910-1
Abstract: Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular basis… read more here.
Keywords: protein; rif1; pp1; mouse rif1 ... See more keywords
Protein phosphatase-1: dual activity regulation by Inhibitor-2.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20200503
Abstract: Inhibitor-2 (I2) ranks amongst the most ancient regulators of protein phosphatase-1 (PP1). It is a small, intrinsically disordered protein that was originally discovered as a potent inhibitor of PP1. However, later investigations also characterized I2… read more here.
Keywords: inhibitor; phosphatase dual; pp1; activity ... See more keywords
Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200780119
Abstract: In the metazoan S phase, coordinated firing of clusters of origins replicates different parts of the genome in a temporal program. Despite advances, neither the mechanism controlling timing nor that coordinating firing of multiple origins… read more here.
Keywords: self stabilizing; pp1; replication; rif1 pp1 ... See more keywords
Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart
Sign Up to like & getrecommendations! Published in 2019 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy171
Abstract: Abstract Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and… read more here.
Keywords: pp1 pp1; heart; differential localizations; pp1 ... See more keywords
The protein phosphatase isoform PP1&ggr;1 substitutes for PP1&ggr;2 to support spermatogenesis but not normal sperm function and fertility†
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy225
Abstract: Abstract Four isoforms of serine/threonine phosphatase type I, PP1&agr;, PP1&bgr;, PP1&ggr;1, and PP1&ggr;2, are derived from three genes. The PP1&ggr;1 and PP1&ggr;2 isoforms are alternately spliced transcripts of the protein phosphatase 1 catalytic subunit gamma… read more here.
Keywords: spermatogenesis; isoform; pp1; pp1 ggr ... See more keywords
Multiplexed Assay to Quantify the PP-Fold Family of Peptides in Human Plasma Using Microflow Liquid Chromatography-Tandem Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvab229
Abstract: BACKGROUND Peptide Tyr-Tyr (PYY1-36), pancreatic polypeptide (PP1-36) and neuropeptide Y (NPY1-36) constitute the PP-fold family of peptides that is involved in metabolic regulation. Very low plasma concentrations and cleavage into active 3-36 fragments challenge bioanalytical… read more here.
Keywords: family peptides; plasma using; pp1; assay quantify ... See more keywords