Sign Up to like & get
recommendations!
0
Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103874
Abstract: We herein report the design, synthesis, and functional impact of an okadaic acid (OA) small analogue, ITH12680, which restores the activity of phosphoprotein phosphatase 2A (PP2A), whose deficient activity has been implicated in nicotine-mediated tumor…
read more here.
Keywords:
pp2a activity;
nicotine induced;
resistance;
cell ... See more keywords
Sign Up to like & get
recommendations!
2
Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0219
Abstract: Sodium selenate (SS) activates protein phosphatase 2 (PP2A) and reduces phosphorylated TAU (pTAU) and late post-traumatic seizures after lateral fluid percussion injury (LFPI). In EpiBioS4Rx Project 2, a multicenter international study for post-traumatic targets, biomarkers…
read more here.
Keywords:
sodium selenate;
epibios4rx project;
pp2a activity;
ptau ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000491657
Abstract: Background/Aims: Alpha-synuclein (α-Syn) is a neuronal protein that is highly implicated in Parkinson’s disease (PD), and protein phosphatase 2A (PP2A) is an important serine/threonine phosphatase that is associated with neurodegenerative diseases, such as PD. α-Syn…
read more here.
Keywords:
protein;
pp2a activity;
mechanism;
syn ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.425
Abstract: β adrenergic receptor (βAR) function is regulated by G-protein coupled receptor (GPCR) kinase (GRK) driven desensitization and protein phosphatase 2A (PP2A) mediated resensitization to its classical agonist. Surprisingly, Insulin modulates (βARs) function thus regulating cardiac…
read more here.
Keywords:
insulin;
pp2a activity;
pi3k;
function ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2018 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2018.00173
Abstract: The pathology of Parkinson’s disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn can regulate PP2A activity.…
read more here.
Keywords:
pp2a activity;
phosphatase;
protein phosphatase;
inhibition ... See more keywords