Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.09.059
Abstract: Summary Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate… read more here.
Keywords: cdk1; pp2a b55; feedback; biology ... See more keywords
PP2A-B55γ counteracts Cdk1 and regulates proper spindle orientation through the cortical dynein adaptor NuMA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.243857
Abstract: ABSTRACT Proper orientation of the mitotic spindle is critical for accurate development and morphogenesis. In human cells, spindle orientation is regulated by the evolutionarily conserved protein NuMA, which interacts with dynein and enriches it at… read more here.
Keywords: spindle orientation; b55; pp2a b55; t2055 ... See more keywords
The Oncogenic Functions of MASTL Kinase
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00162
Abstract: MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase.… read more here.
Keywords: pp2a b55; oncogenic functions; kinase; mastl kinase ... See more keywords
Structural, enzymatic and spatiotemporal regulation of PP2A-B55 phosphatase in the control of mitosis
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DOI: 10.3389/fcell.2022.967909
Abstract: Cells require major physical changes to induce a proper repartition of the DNA. Nuclear envelope breakdown, DNA condensation and spindle formation are promoted at mitotic entry by massive protein phosphorylation and reversed at mitotic exit… read more here.
Keywords: phosphatase; control mitosis; pp2a b55; b55 phosphatase ... See more keywords
Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells
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DOI: 10.3390/ijms21186642
Abstract: Nuclear factor kappa B (NF-κB) activation is a well-known mechanism by which chemoresistance to anticancer agents is reported. It is well-known that irinotecan as a chemotherapeutic drug against non-small-cell lung carcinoma (NSCLC) has limited anticancer… read more here.
Keywords: pp2a b55; gra16; activation; anticancer ... See more keywords