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   Articles with "pp2a b56" as a keyword



Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.07.01.498399

Abstract: Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme. Here… read more here.

Keywords: pme; pp2a b56; pp2a; pme activities ... See more keywords

PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis

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recommendations! Published in 2019 at "EMBO Reports"

DOI: 10.15252/embr.201948503

Abstract: Cell cycle progression and genome stability are regulated by a ubiquitin ligase, the anaphase‐promoting complex/cyclosome (APC/C). Cyclin‐dependent kinase 1 (Cdk1) has long been implicated in APC/C activation; however, the molecular mechanisms of governing this process… read more here.

Keywords: pp2a b56; ubiquitin ligase; cdc20; apc ... See more keywords
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Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

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recommendations! Published in 2019 at "eLife"

DOI: 10.7554/elife.42619

Abstract: PP2A-B56 is a serine/threonine phosphatase complex that regulates several major mitotic processes, including sister chromatid cohesion, kinetochore-microtubule attachment and the spindle assembly checkpoint. We show here that these key functions are divided between different B56… read more here.

Keywords: b56; pp2a b56; b56 isoforms; centromere kinetochore ... See more keywords

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

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recommendations! Published in 2020 at "eLife"

DOI: 10.7554/elife.65307

Abstract: Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore–microtubule… read more here.

Keywords: meiosis; pp2a b56; chromosome congression; congression meiosis ... See more keywords