The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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DOI: 10.1016/j.cell.2021.04.022
Abstract: Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint following transcription initiation is primarily controlled by CDK9. We discovered that… read more here.
Keywords: integrator cdk9; transcription; pp2a integrator; cdk9 ... See more keywords