Hsp90 provides a platform for kinase dephosphorylation by PP5
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.09.02.506407
Abstract: PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and the Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5. The Hsp90 molecular chaperone… read more here.
Keywords: hsp90; kinase; craf; pp5 ... See more keywords
Celastrol ameliorates Cd‐induced neuronal apoptosis by targeting NOX2‐derived ROS‐dependent PP5‐JNK signaling pathway
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DOI: 10.1111/jnc.13966
Abstract: Celastrol, a plant‐derived triterpene, has neuroprotective benefit in the models of neurodegenerative disorders that are characterized by overproduction of reactive oxygen species (ROS). Recently, we have reported that cadmium (Cd) activates c‐Jun N‐terminal kinase (JNK)… read more here.
Keywords: jnk; pp5; neuronal apoptosis; ros dependent ... See more keywords
Plk4 Is a Novel Substrate of Protein Phosphatase 5
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DOI: 10.3390/ijms24032033
Abstract: The conserved Ser/Thr protein phosphatase 5 (PP5) is involved in the regulation of key cellular processes, including DNA damage repair and cell division in eukaryotes. As a co-chaperone of Hsp90, PP5 has been shown to… read more here.
Keywords: novel substrate; pp5; protein phosphatase; plk4 ... See more keywords