Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.036
Abstract: Granulovacuolar degeneration (GVD) was originally reported in Alzheimer's disease (AD) and later found in aging brains. Pathologically, GVD is thought to be associated with the development of tauopathy, but the precise mechanism remains unknown. Previous… read more here.
Keywords: gvd; neurodegenerative diseases; pp65; granulovacuolar degeneration ... See more keywords
CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2169488
Abstract: ABSTRACT Human cytomegalovirus (HCMV) infection is prevalent worldwide, and there is currently no licenced HCMV vaccine to control it. Therefore, developing an effective HCMV vaccine is a significant priority. Because of their excellent immunogenicity, the… read more here.
Keywords: pp65; peptide crm197; crm197 vaccines; hcmv vaccine ... See more keywords
EPCT-13. CMV PP65 RNA-PULSED DENDRITIC CELL VACCINES FOR PEDIATRIC GLIOBLASTOMA AND MEDULLOBLASTOMA: PHASE I TRIAL RESULTS
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DOI: 10.1093/neuonc/noaa222.136
Abstract: Abstract BACKGROUND Recurrent medulloblastoma and malignant glioma are lethal tumors that are virtually incurable. The cytomegalovirus (CMV) antigen pp65 is ubiquitously expressed on medulloblastoma and malignant glioma but not on healthy brain. We evaluated autologous… read more here.
Keywords: pp65 rna; pp65; rna pulsed; cmv pp65 ... See more keywords
Repertoire of Cytomegalovirus-Specific T Cells Is Focused on the Immunodominant Epitopes in Fixed Hierarchy Dependent on HLA Genotype of the Donor
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DOI: 10.1182/blood-2019-130241
Abstract: Background: Cytomegalovirus (HCMV) infection is one of the major complications and causes of mortality in patients receiving immunosuppressive therapy following hematopoietic stem cell transplantation (HSCT). Antiviral drugs have limited efficacy and high toxicity while using… read more here.
Keywords: hla; specific cells; immunodominant epitopes; tpr rph ... See more keywords