Computational and mutational hotspot analysis of mycobacterial inorganic pyrophosphatase and virtual screening of natural compounds to discover contemporary drug candidates: Trilateral approach that explores its GTPase activity.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2381
Abstract: Mycobacterial inorganic pyrophosphatase (Mt-PPa) play essential role in bacterial in vitro and in vivo survival. This family of proteins reacts on inorganic pyrophosphate to release inorganic phosphate and protect bacteria from pyrophosphate toxicity. Rv3628 (Mt-PPa)… read more here.
Keywords: pyrophosphatase; virtual screening; inorganic pyrophosphatase; ppa ... See more keywords
Photosensitizer-Polypeptides Conjugate with Synergistic Antibacterial Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200105
Abstract: Recently, continuous emergence of resistant bacteria has appeared as one of the most serious threats to human health. Therefore, systematic exploration of new antibacterial materials is of guiding significance. In this study, a series of… read more here.
Keywords: photosensitizer polypeptides; polypeptides conjugate; synergistic antibacterial; ppa ... See more keywords
Polyphthalaldehyde: Synthesis, Derivatives, and Applications.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201700519
Abstract: o-Phthalaldehyde is, to this day, the only aromatic aldehyde that can be homopolymerized through chain-growth polymerization. The product, polyphthalaldehyde (PPA), is a brittle white solid, and, having a polyacetal main chain, presents the ability to… read more here.
Keywords: ppa; polyphthalaldehyde synthesis; chemistry; synthesis derivatives ... See more keywords
Dendron-Functionalized Polyglutamate-Pyropheophorbide-a Conjugates as Nanomedicines for Breast Cancer Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100013
Abstract: Photodynamic therapy (PDT) has shown its promise in the treatment of cancer. Herein, a dendron-functionalized polyglutamic acid (PGA) polymer (PG-L8G-Ppa-Dendron, PGPD) is synthesized and it is conjugated with pyropheophorbide-a (Ppa) for the first time to… read more here.
Keywords: photodynamic therapy; ppa; dendron functionalized; breast cancer ... See more keywords
L-carnitine protects DNA oxidative damage induced by phenylalanine and its keto acid derivatives in neural cells: a possible pathomechanism and adjuvant therapy for brain injury in phenylketonuria.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-021-00780-x
Abstract: Although phenylalanine (Phe) is known to be neurotoxic in phenylketonuria (PKU), its exact pathogenetic mechanisms of brain damage are still poorly known. Furthermore, much less is known about the role of the Phe derivatives phenylacetic… read more here.
Keywords: ppa; brain; damage; phe paa ... See more keywords
Primary Progressive Aphasia: Toward a Pathophysiological Synthesis
Sign Up to like & getrecommendations! Published in 2021 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-021-01097-z
Abstract: Purpose of Review The term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems with speech and language. They present considerable challenges to clinicians and researchers.… read more here.
Keywords: variant ppa; ppa; primary progressive; progressive aphasia ... See more keywords
Relationship Between Physiological and Perceived Fall Risk in People With Multiple Sclerosis: Implications for Assessment and Management.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of physical medicine and rehabilitation"
DOI: 10.1016/j.apmr.2018.03.019
Abstract: OBJECTIVE This study evaluated the relationship between physiological and perceived fall risk in people with multiple sclerosis (MS). DESIGN Secondary analysis of data from prospective cohort studies undertaken in Australia, the United Kingdom, and the… read more here.
Keywords: fall risk; risk; ppa; physiological perceived ... See more keywords
Multifunctional isoxazolidine derivatives as α-amylase and α-glucosidase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103713
Abstract: A series of novel isoxazolidines based on benzaldehyde derivatives have been synthesized from the cycloaddition of chiral menthone-based nitrone and allyl phenyl ethers. All synthetic compounds were assessed for their in vitro PPA, HPA and… read more here.
Keywords: ppa hpa; ppa; hpa; hpa hlag ... See more keywords
An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2020.06.013
Abstract: Abstract R-2-(4-hydroxyphenoxy)propionic acid (R-HPPA) is a key intermediate for the synthesis of classic herbicides with high selectivity against grassy weed. The main route for R-HPPA biosynthesis is to hydroxylate the substrate R-2-phenoxypropionic acid (R-PPA) at… read more here.
Keywords: hydroxyphenoxy propionic; ppa; production; acid ... See more keywords
Micellar transition (ellipsoidal to ULV) induced in aqueous Gemini surfactant (12-2-12) solution as a function of additive concentration and temperature using experimental and theoretical study
Sign Up to like & getrecommendations! Published in 2018 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2018.06.070
Abstract: Abstract Micellar aggregates formed in aqueous solution of Gemini surfactant: N, N′-didodecyl-N,N, N′,N′ tetramethyl-N,N′-ethanediyldiammonium dibromide (12-2-12), in presence of organic additive: Phenyl Propiolic acid (PPA), has been systematically characterized by rheology, 1H-NMR, fluorescence spectroscopy, dynamic… read more here.
Keywords: ppa; temperature; microscopy; function ... See more keywords
Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Cortex"
DOI: 10.1016/j.cortex.2016.10.019
Abstract: The majority of logopenic variant primary progressive aphasia (lv-PPA) cases harbour Alzheimer pathology, suggesting that lv-PPA constitutes an atypical presentation of Alzheimer's disease (AD). However, even if caused by Alzheimer pathology, the clinical manifestations of… read more here.
Keywords: anomia amnestic; ppa; word; alzheimer disease ... See more keywords