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   Articles with "ppa1" as a keyword



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Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer

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recommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2022.2038193

Abstract: Abstract Background Circular RNA 0067934 (circ_0067934) has been revealed as a cancer driver in multiple human malignancies, whereas its action in the pathogenesis of ovarian cancer (OC) remains unclear. This study focuses on the function… read more here.

Keywords: mir 545; resistance; circ 0067934; ddp ... See more keywords
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PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARĪ³ Target Gene

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recommendations! Published in 2021 at "Diabetes"

DOI: 10.2337/db20-0622

Abstract: Downregulation of mitochondrial function in adipose tissue is considered as one important driver for the development of obesity-associated metabolic disorders. Inorganic pyrophosphatase 1 (PPA1) is an enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to… read more here.

Keywords: ppa1; ppar target; adipose tissue; function ... See more keywords
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PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.1012090

Abstract: Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo sapiens, as well as significantly in a variety of malignancies. The hydrolysis of… read more here.

Keywords: ppa1 energy; ppa1; role; progression ... See more keywords

Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma.

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recommendations! Published in 2018 at "Oncology letters"

DOI: 10.3892/ol.2018.8278

Abstract: The inorganic pyrophosphatase gene (PPA1) encodes inorganic pyrophosphatase, an enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to orthophosphate, and has been revealed to be dysregulated in several types of human cancer. However, the role… read more here.

Keywords: pyrophosphatase; ppa1; intrahepatic cholangiocarcinoma; future recurrence ... See more keywords