Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL‐4‐stimulated THP‐1 and primary human macrophages
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DOI: 10.1002/2211-5463.12858
Abstract: Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but cross talk between them has not been reported in macrophages. In this study, the effect of Notch signaling on PPARγ in IL‐4‐stimulated human… read more here.
Keywords: ppar; akt; ppar protein; protein stability ... See more keywords
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
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DOI: 10.1002/advs.202411086
Abstract: Gut microbiota is essential for the function of peripherally‐induced regulatory T (pTreg) cells. However, how commensal bacteria affect thymically derived fat‐resident Treg cells that harbor a unique expression of peroxisome proliferator‐activated receptor (PPAR)‐γ and suppress… read more here.
Keywords: ppar; gut microbiota; population; butyrate ... See more keywords
Lipid Droplets Metabolism Mediated by ANXA7‐PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice
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DOI: 10.1002/advs.202417326
Abstract: Spinal cord injury is characterized by high incidence and high disability, and the specific targets and drugs have not yet been explored. Lipid droplet is a type of organelles that regulates lipid metabolism and oxidative… read more here.
Keywords: spinal cord; ppar; lipid droplet; cord injury ... See more keywords
Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways
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DOI: 10.1002/ddr.21956
Abstract: Diabetic nephropathy (DN) is a common complication of diabetes and it is urgent to develop effective therapies for DN. In this study, high‐sucrose and high‐fat diet combined with streptozotocin was used to induce DN in… read more here.
Keywords: inflammation; ppar; ombuin ameliorates; ameliorates diabetic ... See more keywords
The Pro12Ala polymorphism of PPARγ2 modulates beta cell function and failure to oral glucose‐lowering drugs in patients with type 2 diabetes
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DOI: 10.1002/dmrr.3392
Abstract: We evaluate whether the Pro12Ala polymorphism of peroxisome proliferator‐activated receptor γ2 (PPARγ2) has a role in the progression of diabetes by modulating the occurrence of treatment failure to glucose‐lowering drugs. read more here.
Keywords: ppar; failure; lowering drugs; pro12ala polymorphism ... See more keywords
Protective Effects of Atorvastatin on LPS‐Induced Testicular Damage: Modulation of Spermatogenesis via PPAR‐γ, NF‐κB, and NLRP3 Pathways
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DOI: 10.1002/jat.4851
Abstract: Male infertility represents a considerable global health issue, frequently linked to oxidative stress and inflammation‐related dysfunction of the testes. Atorvastatin (ATV), a commonly prescribed statin, has effects that extend beyond merely lowering lipid levels. Recent… read more here.
Keywords: ppar; protective effects; induced testicular; testicular damage ... See more keywords
Antiapoptotic and anti‐inflammatory effects of Pparγ agonist, pioglitazone, reversed Dox‐induced cardiotoxicity through mediating of miR‐130a downregulation in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23041
Abstract: Doxorubicin (Dox) is an antitumor agent widely used in cancer therapy, with notable side effects of cardiac toxicity. Peroxisome proliferator‐activated receptor γ (PPARγ), is a transcriptional factor with antiapoptotic and anti‐inflammatory properties. Recently we indicated… read more here.
Keywords: ppar; mir 130a; dox; dox induced ... See more keywords
microRNA‐211 promotes invasion and migration of colorectal cancer cells by targeting FABP4 via PPARγ
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DOI: 10.1002/jcp.28190
Abstract: Fatty acid binding protein 4 (FABP4) is a novel tumor regulator that is abnormally expressed in many human cancers. In our study, upregulated microRNA‐211 (miR‐211) and reduced FABP4 expression were detected in colorectal cancer (CRC)… read more here.
Keywords: ppar; mir 211; mir; colorectal cancer ... See more keywords
Modulation of PPARα-Thermogenesis-Gut Microbiota Interactions in Obese Mice Administrated with Zingerone.
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DOI: 10.1002/jsfa.12352
Abstract: BACKGROUND The present study aimed to uncover the potential effects of zingerone (ZIN), one of the bioactive compounds in ginger, on the development of obesity as well as the mechanisms in C57BL/6J mice fed with… read more here.
Keywords: adipose tissue; ppar; fed mice; gut microbiota ... See more keywords
Regulatory mechanisms mediated by peroxisome proliferator‐activated receptor‐β/δ in skin cancer
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DOI: 10.1002/mc.23033
Abstract: Considerable progress has been made during the past 20 years towards elucidating the role of peroxisome proliferator‐activated receptor‐β/δ (PPARβ/δ) in skin cancer. In 1999, the original notion that PPARβ/δ was involved with epithelial cell function… read more here.
Keywords: ppar; peroxisome proliferator; proliferator activated; skin cancer ... See more keywords
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and disease.
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DOI: 10.1002/med.21970
Abstract: The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles and unhealthy dietary patterns. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor regulating multiple biological processes, such as lipid metabolism and… read more here.
Keywords: inflammation; peroxisome proliferator; ppar; proliferator activated ... See more keywords