Peroxisome proliferator-activated receptor alpha mediates C/EBP homologous protein to protect mice from acute liver failure
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1061-3
Abstract: ObjectivePeroxisome proliferator-activated receptor α (PPARα) activation has been reported to ameliorate liver injury in cases of acute liver failure (ALF). However, its intrinsic protective molecular mechanisms remain largely undetermined. C/EBP homologous protein (CHOP) is an… read more here.
Keywords: chop; expression; inflammation; ppar activation ... See more keywords
Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α2 adrenoceptors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173733
Abstract: Over the past decade, dexmedetomidine (DEX) has been found to possess an anti-inflammatory effect. However, the local anti-inflammatory mechanism of DEX has not been fully clarified. Some intracellular inflammatory pathways lead to negative feedback during… read more here.
Keywords: inflammatory responses; lps induced; dex; ppar activation ... See more keywords
4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.
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DOI: 10.1016/j.tox.2019.04.004
Abstract: 4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected… read more here.
Keywords: ppar; alcoholic hepatitis; ppar activation; hesperetin ... See more keywords
Polyacetylenes from Oplopanax horridus and Panax ginseng: Relationship between Structure and PPARγ Activation
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DOI: 10.1021/acs.jnatprod.9b00691
Abstract: Oplopanax horridus and Panax ginseng are members of the plant family Araliaceae, which is rich in structurally diverse polyacetylenes. In this work, we isolated and determined structures of 23 aliphatic C17 and C18 polyacetylenes, of… read more here.
Keywords: ppar; ppar activation; oplopanax horridus; panax ginseng ... See more keywords
Metabolomics reveals that PPARα activation protects against lithocholic acid-induced liver injury
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DOI: 10.1039/c7ra08823j
Abstract: Some studies have reported that the activation of peroxisome proliferator-activated receptor alpha (PPARα) could protect against liver injury-induced by chemicals. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOFMS)-based… read more here.
Keywords: induced liver; metabolomics reveals; ppar activation; liver injury ... See more keywords
Is hepatic peroxisome proliferator‐activated receptor α essential for the metabolic effects of fibrates?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14126
Abstract: Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid/nuclear receptor superfamily and functions as a ligand-activated transcription factor. After ligand binding, PPARα forms a heterodimer with the retinoid X receptor, and the heterodimer… read more here.
Keywords: ppar; hepatic ppar; ppar activation; effects fibrates ... See more keywords
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
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DOI: 10.1126/scitranslmed.aal2332
Abstract: PPARδ activation by bexarotene in a mouse model of Huntington’s disease rescues defective oxidative metabolism and is neuroprotective. Defeating neurotoxicity with a repurposed drug PPARδ is a permissive nuclear receptor that heterodimerizes with the retinoid… read more here.
Keywords: ppar; quality control; ppar activation; bexarotene ... See more keywords
PPARγ activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15538
Abstract: Oxidative stress has an important role in brain aging and its consequences include cognitive decline and physiological disorders. Peroxisome proliferator‐activated receptor‐γ (PPARγ) activation has been suggested to decrease oxidative stress. In the current research, the… read more here.
Keywords: stress; pio; oxidative stress; ppar activation ... See more keywords
Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation
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DOI: 10.2337/db17-0983
Abstract: Beige adipocytes can dissipate energy as heat. Elaborate communication between metabolism and gene expression is important in the regulation of beige adipocytes. Although lipid droplet (LD) binding proteins play important roles in adipose tissue biology,… read more here.
Keywords: beige adipocytes; ppar activation; beige; plin3 ... See more keywords
PPARδ Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels
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DOI: 10.3390/antiox11050810
Abstract: Intracellular iron accumulation in dopaminergic neurons contributes to neuronal cell death in progressive neurodegenerative disorders such as Parkinson’s disease. However, the mechanisms of iron homeostasis in this context remain incompletely understood. In the present study,… read more here.
Keywords: induced neuronal; iron; ohda induced; ppar activation ... See more keywords
Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126399
Abstract: Accumulating evidence support the cardioprotective properties of the nuclear receptor peroxisome proliferator activated receptor β/δ (PPARβ/δ); however, the underlying mechanisms are not yet fully elucidated. The aim of the study was to further investigate the… read more here.
Keywords: ischemia reperfusion; ppar activation; activation;