Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s Disease
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DOI: 10.1021/acsomega.2c07521
Abstract: Herein, we rationally designed and developed two novel glitazones (G1 and G2) to target peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) signaling through peroxisome proliferator-activated receptors (PPAR)-γ agonism as a therapeutic for Parkinson’s disease (PD). The… read more here.
Keywords: via ppar; ppar agonism; pgc signaling; parkinson disease ... See more keywords
PPARγ agonism attenuates cocaine cue reactivity
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DOI: 10.1111/adb.12471
Abstract: Cocaine use disorder is a chronic relapsing condition characterized by compulsive drug seeking and taking even after prolonged abstinence periods. Subsequent exposure to drug‐associated cues can promote intense craving and lead to relapse in abstinent… read more here.
Keywords: cocaine; cue reactivity; agonism attenuates; ppar agonism ... See more keywords