A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7413
Abstract: Targeting the PPARγ might be a potential therapeutic strategy for diabetes‐associated cognitive decline (DACD). In this study, Gypenoside LXXV (GP‐75), a dammarane‐type triterpene compound isolated from Gynostemma pentaphyllum, was found to be a novel PPARγ… read more here.
Keywords: ppar; ppar agonist; brain; akt ... See more keywords
Inflammatory Response Modulation through a PPARγ Agonist during Surgically Induced Visceral Ischemia in an Animal Model.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2017.09.019
Abstract: BACKGROUND Ischemia/reperfusion (I/R) injury represents one of the most severe complications in vascular surgery where cross-clamping of the aorta and subsequent visceral ischemia are a recurrent issue. The literature describes a family of nuclear receptors,… read more here.
Keywords: visceral ischemia; inflammatory response; ppar agonist; model ... See more keywords
Anti-inflammatory effects of an optimized PPAR-γ agonist via NF-κB pathway inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103611
Abstract: In our previous study, a PPAR-γ agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico analysis showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr473 of PPAR-γ LBD (ligand binding domain). To facilitate… read more here.
Keywords: anti inflammatory; pathway inhibition; inhibition; via pathway ... See more keywords
Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103803
Abstract: Many peroxisome proliferator-activated receptors (PPARs) agonists have been developed for the treatment of metabolic disorders, while several PPARs agonists were discontinued in clinical trials because of PPARγ related side effects. In order to increase the… read more here.
Keywords: ppar; non alcoholic; dual ppar; treatment ... See more keywords
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110801
Abstract: Mercury (Hg) pollution poses global human health and environmental risks. However, still knowledge gaps exist on both exposures and health effects. Here, we combined transcriptome sequencing technique to further investigate the specific mechanisms of inorganic… read more here.
Keywords: induced nephrotoxicity; ppar agonist; translocation; hgcl2 ... See more keywords
PPARα agonist alleviates tumor growth and chemo-resistance associated with the inhibition of glucose metabolic pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172664
Abstract: As a nuclear receptor, peroxisome-proliferator-activated receptor α (PPARα) plays a critical role in regulation of metabolism and cancer, while the effect of PPARα agonist on cancer cell glucose metabolism-linked tumor growth is still unclear. Here… read more here.
Keywords: ppar agonist; growth chemo; cancer; wy14 643 ... See more keywords
Treatment of PAH with a PPARγ agonist
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0029-5
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Cardiology activation of peroxisome proliferator-activated receptor-γ (PParγ) with pioglitazone reverses metabolic changes that occur with pulmonary arterial hypertension (PaH). these… read more here.
Keywords: cardiology; treatment; ppar agonist; pah ppar ... See more keywords
Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20193767
Abstract: Abstract Hydroxyoctadecadienoic acids (HODEs) are produced by oxidation and reduction of linoleates. There are several regio- and stereo-isomers of HODE, and their concentrations in vivo are higher than those of other lipids. Although conformational isomers… read more here.
Keywords: hode isomers; ppar agonist; hydroxyoctadecadienoic acids; activity ... See more keywords
Effects of PPAR-γ agonist, pioglitazone on brain tissues oxidative damage and learning and memory impairment in juvenile hypothyroid rats
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2019.1632843
Abstract: Abstract Aim: The effect of peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist pioglitazone on the brain tissues oxidative damage and learning and memory impairment in the juvenile hypothyroid rats was evaluated. Main methods: Rats were classified as:… read more here.
Keywords: brain tissues; ptu; ppar agonist; agonist pioglitazone ... See more keywords
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14019
Abstract: Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been extensively investigated, the bioactivity of… read more here.
Keywords: acid potent; agonist neuroprotective; potent ppar; ppar agonist ... See more keywords
Anti-fibrotic effect of ciglitazone in HRV-induced airway remodelling cell model.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17790
Abstract: Fibrosis is an important phenomenon as it can occur early in the pathogenesis of asthma; it may be associated with disease severity and resistance to therapy. There is a strong evidence that infection caused by… read more here.
Keywords: ppar agonist; hrv; expression; airway remodelling ... See more keywords