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   Articles with "ppar agr" as a keyword



PPAR&agr;/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.09.008

Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Recent studies have demonstrated the utility of drugs modulating the endogenous cannabinoid system to control excessive alcohol intake. Among them, drugs interacting with acylethanolamide receptors including cannabinoid CB1… read more here.

Keywords: ppar agr; cb1 receptor; receptor; dual ligands ... See more keywords
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Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward

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recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.11.013

Abstract: &NA; Tobacco smoke is the leading preventable cause of death in the world and treatments aimed to increase success rate in smoking cessation by reducing nicotine dependence are sought. Activation of peroxisome proliferator‐activated receptor‐alpha (PPAR&agr;)… read more here.

Keywords: nicotine; ppar agr; nicotine induced; dopamine ... See more keywords
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Oleoylethanolamide inhibits glial activation via moudulating PPAR&agr; and promotes motor function recovery after brain ischemia

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recommendations! Published in 2019 at "Pharmacological Research"

DOI: 10.1016/j.phrs.2019.01.027

Abstract: &NA; Glial activation and scar formation impede the neurological function recovery after cerebral ischemia. Oleoylethanolamide (OEA), a bioactive lipid mediator, shows neuroprotection against acute brain ischemia, however, its long‐term effect, especially on glial scar formation,… read more here.

Keywords: motor function; glial activation; ppar agr; brain ischemia ... See more keywords
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Investigation of the mechanism of triclosan induced mouse liver tumors

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recommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"

DOI: 10.1016/j.yrtph.2017.03.001

Abstract: &NA; Chronic dietary exposure to Triclosan (TCS) produced increased incidence of liver tumors in mice. The mechanism for liver tumor induction has been attributed to activation of either peroxisome proliferator activated receptor &agr; (PPAR&agr;) or… read more here.

Keywords: liver tumors; ppar agr; car; liver ... See more keywords
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Nutrient-sensing nuclear receptors PPAR&agr; and FXR control liver energy balance

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recommendations! Published in 2017 at "Journal of Clinical Investigation"

DOI: 10.1172/jci88893

Abstract: The nuclear receptors PPAR&agr; (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively. PPAR&agr; activation induces fatty acid oxidation, while FXR… read more here.

Keywords: liver energy; nuclear receptors; ppar agr; agr fxr ... See more keywords