Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway.
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DOI: 10.1016/j.bcp.2020.114136
Abstract: Oridonin is a diterpene compound that regulates the activity of PPAR-γ (peroxisome proliferator-activated receptor gamma) transcription factor. Cumulative evidence indicates that AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) play an important role in the treatment… read more here.
Keywords: ppar; treatment; ampa receptor; receptor signaling ... See more keywords