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   Articles with "ppar ggr" as a keyword



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Silencing LAIR‐1 in human THP‐1 macrophage increases foam cell formation by modulating PPAR&ggr; and M2 polarization

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recommendations! Published in 2018 at "Cytokine"

DOI: 10.1016/j.cyto.2018.08.028

Abstract: Graphical abstract Figure. No caption available. HighlightsLAIR‐1 was down‐regulated in macrophage with the stimulation of ox‐LDL.Silencing expression of LAIR‐1 in human macrophages increased cholesterol uptake.LAIR‐1 activated phosphorylation of SHP‐1 and CREB to induce PPAR&ggr;, thus… read more here.

Keywords: cell formation; lair; foam cell; ppar ggr ... See more keywords
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Epigallocatechin‐3‐gallate inhibits adipogenesis through down‐regulation of PPAR&ggr; and FAS expression mediated by PI3K‐AKT signaling in 3T3‐L1 cells

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recommendations! Published in 2017 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2016.12.006

Abstract: ABSTRACT Epigallocatechin‐3‐gallate (EGCG), a major component in green tea, functions as extensive bioactivities including anti‐inflammation, anti‐oxidation, and anti‐cancer. However, little is known about its anti‐adipogenesis and underlying mechanisms. The purport of this study sought to… read more here.

Keywords: akt; adipogenesis; ggr fas; ppar ggr ... See more keywords
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PPARgamma agonists sensitize PTEN‐deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.01.036

Abstract: Abstract We aimed to develop novel drug combination strategy to overcome drug resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) in the treatment of non‐small cell lung cancer (NSCLC). Peroxisome proliferator‐activated receptor… read more here.

Keywords: ppar ggr; ggr agonists; ggr; lung cancer ... See more keywords
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Beneficial effects of rosiglitazone, a peroxisome proliferator‐activated receptor‐&ggr; agonist, in a mouse allergic asthma model is not associated with the recruitment or generation of Foxp3‐expressing CD4+ regulatory T cells

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recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2019.01.053

Abstract: &NA; The activation of peroxisome proliferator‐activated receptor &ggr; (PPAR‐&ggr;) has been shown to attenuate allergic airway inflammation (AAI). To gain better understanding of mechanisms underlying this effect, the impact of rosiglitazone (RSG), a PPAR‐&ggr; agonist,… read more here.

Keywords: peroxisome proliferator; effect; ppar ggr; ggr ... See more keywords
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Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice

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recommendations! Published in 2018 at "Experimental Gerontology"

DOI: 10.1016/j.exger.2017.12.002

Abstract: &NA; Pioglitazone (Piog) activates peroxisome proliferator activated receptor‐&ggr; (PPAR&ggr;) and is widely used in clinic for the treatment of diabetes mellitus. PPAR&ggr; in various tissues has the essential regulatory role of multiple metabolic function, suggest… read more here.

Keywords: pioglitazone; aging related; ppar ggr; mice ... See more keywords

The Nuclear Receptor PPAR&ggr; Controls Progressive Macrophage Polarization as a Ligand‐Insensitive Epigenomic Ratchet of Transcriptional Memory

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.09.005

Abstract: Graphical Abstract Figure. No caption available. SUMMARY Macrophages polarize into distinct phenotypes in response to complex environmental cues. We found that the nuclear receptor PPAR&ggr; drove robust phenotypic changes in macrophages upon repeated stimulation with… read more here.

Keywords: ligand insensitive; insensitive ppar; polarization; ppar ggr ... See more keywords
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Wogonin attenuates inflammation by activating PPAR‐&ggr; in alcoholic liver disease

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.06.013

Abstract: Abstract Alcoholic liver disease (ALD) is one of the predominant causes of liver‐related morbidity and mortality worldwide. However, effective therapy for ALD is still lacking. Wogonin, a major flavonoid compound, is found in Scutellaria baicalensis… read more here.

Keywords: ppar; wogonin; alcoholic liver; ppar ggr ... See more keywords
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Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPAR&ggr;/Nrf2/NF‐&kgr;B signaling pathway

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recommendations! Published in 2019 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.11.044

Abstract: &NA; Luteoloside, a flavonoid compound, has been reported to have anti‐inflammatory, anti‐oxidative, antibacterial, antiviral, anticancer, and cardioprotective effects, among others, but its neuroprotective effects have rarely been studied. The purpose of this study was to… read more here.

Keywords: kgr signaling; cerebral ischemia; focal cerebral; ppar ggr ... See more keywords
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The lipid moiety 7‐ketocholesteryl‐9‐carboxynonanoate mediates binding interaction of oxLDL to LOX‐1 and upregulates ABCA1 expression through PPAR&ggr;

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recommendations! Published in 2017 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.03.024

Abstract: Aim: Lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1), a specific membrane receptor for oxidized low‐density lipoprotein (oxLDL), plays a crucial role in atherosclerosis progression. The aim of this study was to elucidate the role of 7‐ketocholesteryl‐9‐carboxynonanoate… read more here.

Keywords: ppar ggr; abca1 expression; lox;
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Ginsenoside Re prevents angiotensin II‐induced gap‐junction remodeling by activation of PPAR&ggr; in isolated beating rat atria

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recommendations! Published in 2017 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.09.027

Abstract: Aims: Ginsenoside Re (G‐Re), a major ginsenoside in ginseng, has many beneficial pharmacological effects on negative cardiac contractility, electromechanical alternans, antiarrhythmia, angiogenic regeneration and cardiac electrophysiological function. However, effects of G‐Re on gap‐junction remodeling are… read more here.

Keywords: junction remodeling; gap junction; beating rat; ppar ggr ... See more keywords

PPAR-γ agonist GL516 reduces oxidative stress and apoptosis occurrence in a rat astrocyte cell line

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recommendations! Published in 2019 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2019.03.021

Abstract: Aims: The worldwide increase in aging population is prevalently associated with the increase of neurodegenerative diseases. Peroxisome Proliferator‐Activated Receptors (PPARs) are ligand‐modulated transcriptional factors which belong to the nuclear hormone receptor superfamily which regulates peroxisome… read more here.

Keywords: ppar; agonist gl516; ppar ggr; apoptosis occurrence ... See more keywords