PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates
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DOI: 10.1016/j.isci.2020.101727
Abstract: Summary Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been deposited in the Protein Data Bank since 2001;… read more here.
Keywords: ppar; binding domain; ppar ligand; endogenous fatty ... See more keywords
Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity.
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DOI: 10.1016/j.phytochem.2020.112301
Abstract: A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica… read more here.
Keywords: ligand binding; binding activity; ppar ligand;
MMPP promotes adipogenesis and glucose uptake via binding to the PPARγ ligand binding domain in 3T3-L1 MBX cells
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DOI: 10.3389/fphar.2022.994584
Abstract: Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor involved in adipogenesis, and its transcriptional activity depends on its ligands. Thiazolidinediones (TZDs), well-known PPARγ agonists, are drugs that improve insulin resistance in type 2 diabetes. However,… read more here.
Keywords: ppar ligand; mmpp; ligand binding; binding domain ... See more keywords