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   Articles with "ppar lxr" as a keyword



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Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.

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recommendations! Published in 2022 at "Life sciences"

DOI: 10.1016/j.lfs.2022.120571

Abstract: Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy production. CI deficiency is associated with a variety of clinical phenotypes, including Leigh syndrome.… read more here.

Keywords: deficiency; nad levels; nad; cellular nad ... See more keywords

Juniper Berries Regulate Diabetes and Obesity Markers Through Modulating PPARα, PPARγ, and LXR: In Vitro and In Vivo Effects.

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recommendations! Published in 2023 at "Journal of medicinal food"

DOI: 10.1089/jmf.2022.0146

Abstract: The berries of Juniperus communis have been traditionally used for therapeutic purposes. They have been reported to possess various pharmacological effects such as anti-inflammatory, hypoglycemic and hypolipidemic activities. In this study, a methanolic extract of… read more here.

Keywords: ppar lxr; ppar ppar; ppar; juniper berries ... See more keywords

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner

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recommendations! Published in 2017 at "Cellular Physiology and Biochemistry"

DOI: 10.1159/000484031

Abstract: Background/Aims: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the effects of… read more here.

Keywords: ppar; cholesterol; ppar lxr; foam cells ... See more keywords

Abstract 4119262: Anti-atherosclerotic Potential of M2 Macrophage-Derived Exosomes by Promoting Cholesterol Efflux of Foam Cell-Like Vascular Smooth Muscle Cells via the PPARγ-LXRα-ABCA1/ ABCG1 Pathway

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recommendations! Published in 2024 at "Circulation"

DOI: 10.1161/circ.150.suppl_1.4119262

Abstract: Background: Impediment in the excretion of lipid deposits within SMC-derived foam cells (SMC-FCs) is one of the reasons for the continuous expansion of the plaque necrotic core. This study aims to explore the effect and… read more here.

Keywords: smc fcs; abca1; cholesterol efflux; abca1 abcg1 ... See more keywords