FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.041
Abstract: PURPOSE The purpose of this study was to investigate the effect of FNDC5 expression levels in hepatocellular carcinoma on the phenotypic changes of macrophages in tumor tissues. METHODS In this study, we established an in vitro… read more here.
Keywords: hepatocellular carcinoma; carcinoma; affecting ppar; carcinoma cells ... See more keywords
Inhibitory effect of PPARγ on NLRP3 inflammasome activation
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DOI: 10.7150/thno.46873
Abstract: Rationale: Stimulation of the NLRP3 inflammasome by metabolic byproducts is known to result in inflammatory responses and metabolic diseases. However, how the host controls aberrant NLRP3 inflammasome activation remains unclear. PPARγ, a known regulator of… read more here.
Keywords: ppar; inflammasome activation; effect ppar; nlrp3 inflammasome ... See more keywords