Prostaglandin 15d-PGJ2 targets PPARγ and opioid receptors to prevent muscle hyperalgesia in rats.
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DOI: 10.1097/wnr.0000000000001575
Abstract: Pharmacological agents directed to either opioid receptors or peroxisome proliferator-activated receptor gamma (PPARγ) at peripheral tissues reduce behavioral signs of persistent pain. Both receptors are expressed in muscle tissue, but the contribution of PPARγ activation… read more here.
Keywords: ppar opioid; muscle; muscle hyperalgesia; opioid receptors ... See more keywords