The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial‐to‐mesenchymal transition and lipid‐derived energy production in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12818
Abstract: Early stage localized prostate cancer (PCa) has an excellent prognosis; however, patient survival drops dramatically when PCa metastasizes. The molecular mechanisms underlying PCa metastasis are complex and remain unclear. Here, we examine the role of… read more here.
Keywords: mesenchymal transition; production; energy production; prostate cancer ... See more keywords
Tributyltin triggers lipogenesis in macrophages via modifying PPARγ pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.116331
Abstract: Tributyltin (TBT), a bioaccumulative and persistent environmental pollutant, has been proposed as a metabolism disruptor and obesogen through targeting peroxisome proliferator-activated receptor gamma (PPARγ) receptor pathway. However, it remains unknown whether this biological effect occurs… read more here.
Keywords: metabolism; tributyltin; tbt; ppar pathway ... See more keywords
Telmisartan ameliorates LPS‐induced pneumonia in rats through regulation of the PPARγ/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12981
Abstract: Pneumonia is a common disorder of the respiratory system associated with inflammation. Telmisartan (TEL) has been reported to treat inflammatory‐related diseases. The current study aimed to investigate the possible role and action mechanism of telmisartan… read more here.
Keywords: pneumonia rats; induced pneumonia; lps induced; telmisartan ... See more keywords
Glucagon‐like peptide‐1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12763
Abstract: Lipotoxicity cardiomyopathy is the result of excessive accumulation and oxidation of toxic lipids in the heart. It is a major threat to patients with diabetes. Glucagon‐like peptide‐1 (GLP‐1) has aroused considerable interest as a novel… read more here.
Keywords: ppar pathway; glucagon like; lipotoxicity; cardiomyopathy ... See more keywords
Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR-γ Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/9152960
Abstract: Cervical spondylotic radiculopathy (CSR) is the most general form of spinal degenerative disease and is characterized by pain and numbness of the neck and arm. Gentongping (GTP) granule, as a classical Chinese patent medicine, has… read more here.
Keywords: ppar pathway; cervical spondylotic; spondylotic radiculopathy; gtp ... See more keywords
Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/3271057
Abstract: Background The pharmacological mechanism of the traditional Chinese medicine formula-Jijiu Huiyang decoction (JJHYD), which contains several herbal medicines for the treatment of chronic heart failure (CHF), is yet unknown. Method and Materials. The main active… read more here.
Keywords: paeonol; heart; gsk3a; ppar pathway ... See more keywords
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s229063
Abstract: Objective Hepatic ischemia reperfusion (IR) limits the development of liver transplantation technology. The aim of this study was to explore the protective effects of Bergenin on hepatic IR, particularly the elimination of reactive oxygen species… read more here.
Keywords: apoptosis autophagy; ppar pathway; bergenin; release ... See more keywords
Astragaloside IV regulates autophagy-mediated proliferation and apoptosis in a rat model of PCOS by activating the PPARγ pathway
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64475.14179
Abstract: Objective(s): Astragaloside IV (AS-IV) is a bioactive saponin with a wide range of pharmacological effects. This study was aimed at investigating its potential effect on polycystic ovary syndrome (PCOS). Materials and Methods: Female Sprague-Dawley rats… read more here.
Keywords: apoptosis; proliferation; rat; pcos ... See more keywords
Dysregulation of the Amniotic PPARγ Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPARγ in Human Fetal Membranes
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12040544
Abstract: Phthalates are reprotoxic pollutants that are omnipresent in the environment. Detectable in amniotic fluid, these compounds (with the most concentrated being mono-2-ethylhexyl phthalate (MEHP)) are in direct contact with fetal membranes (FMs). They can lead… read more here.
Keywords: ppar; fetal membranes; anti inflammatory; activity ... See more keywords