Effects of telmisartan on TNFα induced PPARγ phosphorylation and insulin resistance in adipocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.091
Abstract: BACKGROUND Telmisartan is an angiotensin II receptor blocker (ARB) and a partial agonist of peroxisome proliferator activated receptor γ (PPARγ). It has been shown to significantly enhance insulin sensitivity in clinical studies and in vitro experiments.… read more here.
Keywords: insulin; tnf; ppar phosphorylation; effects telmisartan ... See more keywords
A Novel Peroxisome Proliferator-Activated Receptor Gamma Ligand Improves Insulin Sensitivity and Promotes Browning of White Adipose Tissue in Obese Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2021.101363
Abstract: OBJECTIVE Nuclear receptor Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a promising target for the treatment of type 2 diabetes. The antidiabetic drug thiazolidinediones (TZDs) are potent insulin sensitizers as full agonists of PPARγ but cause… read more here.
Keywords: energy expenditure; ppar phosphorylation; sensitivity; insulin sensitivity ... See more keywords
Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47672-w
Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a major therapeutic target for the treatment of type 2 diabetes. However, the use of PPARγ-targeted drugs, such as rosiglitazone and pioglitazone, is limited owing to serious side effects… read more here.
Keywords: ppar; ppar phosphorylation; novel reversible; phosphorylation ... See more keywords
Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040694
Abstract: PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented… read more here.
Keywords: biological screening; phosphorylation; ppar phosphorylation; hydroxy lactone ... See more keywords