Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.09.071
Abstract: Peroxisome proliferator-activated receptors (PPARs) play an important role in numerous chronic diseases such as diabetes, obesity, atherosclerosis and cancer, and PPAR modulators are among the approved drugs and drug-candidates for their treatment. The aim of… read more here.
Keywords: ppar; peroxisome proliferator; ppar ppar; proliferator activated ... See more keywords
The role of peroxisome proliferator-activated receptors in healthy and diseased eyes.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108617
Abstract: Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism. Three subtypes of PPARs are known: PPAR-alpha (PPARα), PPAR-gamma (PPARγ), and PPAR-beta/delta (PPARβ/δ). PPARα… read more here.
Keywords: ppar; peroxisome proliferator; ppar ppar; proliferator activated ... See more keywords
Identification of PPAR-activating compounds in herbal and edible plants and fungi from Vietnam
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2018.12.003
Abstract: Abstract Obesity is a major health problem in the world, and it relates to type2-diabetes, heart disease and stroke. The peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARδ, and PPARγ are important regulators of lipid metabolism… read more here.
Keywords: metabolic syndrome; plants fungi; ppar ppar; ppar activating ... See more keywords
The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Autoimmunity"
DOI: 10.1016/j.jaut.2020.102510
Abstract: Abstract Autoimmune diseases are common diseases of the immune system that are characterized by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune tolerance and the prolonged inflammatory reaction are undisputedly… read more here.
Keywords: ppar agonists; ppar ppar; roles ppar; autoimmune diseases ... See more keywords
Antidiabetic Effect of a Flavonoid-Rich Extract from Sophora alopecuroides L. in HFD- and STZ- Induced Diabetic Mice through PKC/GLUT4 Pathway and Regulating PPARα and PPARγ expression.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113654
Abstract: HEADINGS ETHNOPHARMACOLOGICAL RELEVANCE Sophora alopecuroides L. is a traditional ethnopharmacological plant, which is widely used in traditional Chinese medicine and Mongolian and Uighur medicine to ameliorate "thirst disease". AIM OF THE STUDY This study aimed… read more here.
Keywords: medicine; ppar ppar; expression; sophora alopecuroides ... See more keywords
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.05.003
Abstract: To examine the functional role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and PPARγ in skin cancer, stable cell lines were created in the A431 human squamous cell carcinoma cell line. Expression of PPAR target genes was… read more here.
Keywords: ppar; ligand activation; ppar ppar; expression ... See more keywords
Knockout and Restoration Reveal Differential Functional Roles of PPARγ1 and PPARγ2 in Chicken Adipogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05549
Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipogenesis and is expressed as two isoforms, PPARγ1 and PPARγ2. Our previous lentiviral overexpression study showed that PPARγ1 and PPARγ2 differentially regulated proliferation, differentiation, and… read more here.
Keywords: adipogenesis; ppar ppar; ppar; proliferation ... See more keywords
PPAR control of metabolism and cardiovascular functions
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DOI: 10.1038/s41569-021-00569-6
Abstract: Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription factors that regulate gene expression following ligand activation. PPARα increases cellular fatty acid uptake, esterification and trafficking, and regulates lipoprotein metabolism genes. PPARδ stimulates lipid and… read more here.
Keywords: ppar; ppar ppar; heart; metabolism ... See more keywords
Juniper Berries Regulate Diabetes and Obesity Markers Through Modulating PPARα, PPARγ, and LXR: In Vitro and In Vivo Effects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal food"
DOI: 10.1089/jmf.2022.0146
Abstract: The berries of Juniperus communis have been traditionally used for therapeutic purposes. They have been reported to possess various pharmacological effects such as anti-inflammatory, hypoglycemic and hypolipidemic activities. In this study, a methanolic extract of… read more here.
Keywords: ppar lxr; ppar ppar; ppar; juniper berries ... See more keywords
Editor’s Highlight: PPAR&bgr;/&dgr; and PPAR&ggr; Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx147
Abstract: Skin tumorigenesis results from DNA damage, increased inflammation, and evasion of apoptosis. The peroxisome proliferator-activated receptors (PPARs) can modulate these mechanisms in non-melanoma skin cancer. However, limited data exists regarding the role of PPARs in… read more here.
Keywords: ppar; ligand activation; ppar ppar; compared controls ... See more keywords
Kaempferol reduces hepatic triglyceride accumulation by inhibiting Akt.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13034
Abstract: In this paper, we studied the mechanism of the triglyceride (TG)-lowering effect of kaempferol in vitro and in vivo. Kaempferol showed LXR agonistic activities without inducing TGs or the expression of several lipogenic genes in… read more here.
Keywords: ppar; lowering effect; ppar ppar; kaempferol ... See more keywords