Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL‐4‐stimulated THP‐1 and primary human macrophages
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DOI: 10.1002/2211-5463.12858
Abstract: Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but cross talk between them has not been reported in macrophages. In this study, the effect of Notch signaling on PPARγ in IL‐4‐stimulated human… read more here.
Keywords: ppar; akt; ppar protein; protein stability ... See more keywords
Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes
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DOI: 10.3390/ijms18020361
Abstract: Genome polymorphisms are responsible for phenotypic differences between humans and for individual susceptibility to genetic diseases and therapeutic responses. Non-synonymous single-nucleotide polymorphisms (nsSNPs) lead to protein variants with a change in the amino acid sequence… read more here.
Keywords: protein; ppar; ppar protein; single nucleotide ... See more keywords