Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-022-06537-w
Abstract: Neiyi Prescription of QIU (NYPQ) is a traditional Chinese medicine prescription for the treatment of endometriosis (EMS). Here, we aimed to examine the effects and mechanisms of NYPQ on angiogenic ability in EMS. EMS rats… read more here.
Keywords: prescription; angiogenic ability; endometriosis; ppar signaling ... See more keywords
Feedback repression of PPARα signaling by Let-7 microRNA
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109506
Abstract: SUMMARY Peroxisome proliferator-activated receptor α (PPARα) controls hepatic lipid homeostasis and is the target of lipid-lowering fibrate drugs. PPARα activation represses expression of let-7 microRNA (miRNA), but the function of let-7 in PPARα signaling and… read more here.
Keywords: ppar signaling; let microrna; hep mice; let7b hep ... See more keywords
CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29633-6
Abstract: Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic chromatin remodeling enzyme, is essential for the development of organs. The mutation of CHD7 is the main cause of CHARGE syndrome, but its function and mechanism… read more here.
Keywords: signaling chd7; balance; chd7 regulates; ppar signaling ... See more keywords
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9949
Abstract: Healthy guts exclude oxygen Normally, the lumen of the colon lacks oxygen. Fastidiously anaerobic butyrate-producing bacteria thrive in the colon; by ablating these organisms, antibiotic treatment removes butyrate. Byndloss et al. discovered that loss of… read more here.
Keywords: ppar signaling; expansion; butyrate; microbiota activated ... See more keywords
Palmitate Induces Mitochondrial Energy Metabolism Disorder and Cellular Damage via the PPAR Signaling Pathway in Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s360931
Abstract: Purpose To establish an in vitro lipotoxicity model with mouse cardiomyocytes (MCMs) and investigate the molecular mechanism of the peroxisome proliferator-activated receptors (PPAR) signaling on mitochondrial energy metabolism disorder and cellular injury in diabetic cardiomyopathy… read more here.
Keywords: metabolism; energy metabolism; ppar; ppar signaling ... See more keywords
Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.873382
Abstract: Adiponectin (APN), a fat-derived plasma hormone, is a classic anti-inflammatory agent. Multiple studies have demonstrated the beneficial role of APN in acute brain injury, but the effect of APN in germinal matrix hemorrhage (GMH) is… read more here.
Keywords: ampk ppar; brain; adipor1 appl1; ppar signaling ... See more keywords
Transcriptomic Analysis Revealed an Important Role of Peroxisome-Proliferator-Activated Receptor Alpha Signaling in Src Homology Region 2 Domain-Containing Phosphatase-1 Insufficiency Leading to the Development of Renal Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.847512
Abstract: In kidney transplantation, the donor kidney inevitably undergoes ischemia-reperfusion injury (IRI). It is of great importance to study the pathogenesis of IRI and find effective measures to attenuate acute injury of renal tubules after ischemia-reperfusion.… read more here.
Keywords: iri; insufficiency; ppar signaling; injury ... See more keywords
Hepatoprotective Effect of Oplopanax elatus Nakai Adventitious Roots Extract by Regulating CYP450 and PPAR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.761618
Abstract: O. elatus Nakai is a traditional medicine that has been confirmed to exert effective antioxidant and anti-inflammatory functions, and is used for the treatment of different disorders. However, its potential beneficial effects on drug induced… read more here.
Keywords: metabolism; signaling pathway; effect; elatus nakai ... See more keywords
Nephropathy 1st inhibits renal fibrosis by activating the PPARγ signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.992421
Abstract: Renal fibrosis is a manifestation of kidney injury. Nephropathy 1st is a traditional Chinese herbal medicine that has been used as a therapy for kidney disease, but the underlying mechanisms remain elusive. The aim of… read more here.
Keywords: ppar signaling; nephropathy 1st; 1st inhibits; renal fibrosis ... See more keywords
The Protective Effects of Iron Free Lactoferrin on Lipopolysaccharide-Induced Intestinal Inflammatory Injury via Modulating the NF-κB/PPAR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11213378
Abstract: Research evidence shows that effective nutritional intervention could prevent or reduce intestinal inflammatory injury in newborn infants. Iron free lactoferrin (apo-LF), one of the main types of lactoferrin (LF), is a bioactive protein in milk… read more here.
Keywords: inflammatory injury; signaling pathway; iron free; intestinal inflammatory ... See more keywords
PPAR Signaling Maintains Metabolic Homeostasis under Hypothermia in Freshwater Drum (Aplodinotus grunniens)
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13010102
Abstract: Aplodinotus grunniens, known as freshwater drum, is a kind of eurythermal freshwater fish that is widely distributed in North America. In 2019, our research group reached a milestone on its artificial breeding and cultivation and… read more here.
Keywords: hypothermia; ppar signaling; metabolic homeostasis; freshwater drum ... See more keywords