Keratin 23 Is a Peroxisome Proliferator‐Activated Receptor Alpha–Dependent, MYC‐Amplified Oncogene That Promotes Hepatocyte Proliferation
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DOI: 10.1002/hep.30530
Abstract: Chronic activation of the nuclear receptor peroxisome proliferator–activated receptor alpha (PPARA) promotes MYC‐linked hepatocellular carcinoma (HCC) in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not… read more here.
Keywords: peroxisome proliferator; ppara; proliferation; expression ... See more keywords
Hepatic PPARα is critical in the metabolic adaptation to sepsis.
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DOI: 10.1016/j.jhep.2018.12.037
Abstract: BACKGROUND & AIMS Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which… read more here.
Keywords: ppar; sepsis; ppara; hepatic ppar ... See more keywords
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
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DOI: 10.1080/15548627.2019.1596488
Abstract: ABSTRACT Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance between the production and clearance of Aβ (amyloid beta) is considered to be actively involved in AD pathogenesis. Macroautophagy/autophagy is a major cellular… read more here.
Keywords: protein; ppara; disease; beta ... See more keywords