Alterations in GRHL2-OVOL2-ZEB1 axis and aberrant activation of wnt signaling lead to altered gene transcription in posterior polymorphous corneal dystrophy.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107696
Abstract: Mutations associated with posterior polymorphous corneal dystrophy (PPCD) have been identified in three genes: ZEB1 (zinc-finger E-box binding homeobox 1) associated with sub-type PPCD3; OVOL2 (ovol-like zinc finger 2) associated with sub-type PPCD1; and GRHL2… read more here.
Keywords: corneal; wnt signaling; genetically unresolved; ppcd ... See more keywords
Unilateral posterior polymorphous corneal dystrophy due to a novel ZEB1 gene mutation in a Korean girl
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2022.2106495
Abstract: Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant inherited disease that usually develops in the second and third decades of life and triggers bilateral endothelial abnormalities. It is known that PPCD is typically not… read more here.
Keywords: posterior polymorphous; ppcd; corneal; zeb1 ... See more keywords
PPCD: Privacy-preserving clinical decision with cloud support
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0217349
Abstract: With the prosperity of machine learning and cloud computing, meaningful information can be mined from mass electronic medical data which help physicians make proper disease diagnosis for patients. However, using medical data and disease information… read more here.
Keywords: privacy preserving; ppcd; preserving clinical; clinical decision ... See more keywords