Treatment and outcomes in pheochromocytomas and paragangliomas: a study of 110 cases from a single center
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1734-x
Abstract: PurposeMany pheochromocytomas and paragangliomas (PPGLs) are nowadays diagnosed as incidentalomas or by screening. This may have changed outcomes.MethodsWe reviewed 110 consecutive cases of PPGLs. Two cases with concurrent ectopic ACTH-syndrome were excluded.ResultsSixty-five percent had presented… read more here.
Keywords: surgery; treatment outcomes; outcomes pheochromocytomas; pheochromocytomas paragangliomas ... See more keywords
Seizures in patients with a phaeochromocytoma/paraganglioma (PPGL): A review of clinical cases and postulated pathological mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Revue neurologique"
DOI: 10.1016/j.neurol.2018.11.007
Abstract: The purpose of this work was to expound on the postulated pathological mechanisms through which pheochromocytoma/paraganglioma (PPGL) can cause seizures by conducting a comprehensive review of ten cases and several pathogenic mechanisms. The goal was… read more here.
Keywords: paraganglioma ppgl; review; pathological mechanisms; ppgl ... See more keywords
SENSITIVITY AND SPECIFICITY OF 24 HOURS URINARY 3-METHOXYTYRAMINES IN THE DIAGNOSIS OF MALIGNANT PHEOCHROMOCYTOMA AND PARAGANGLIOMA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539342.92258.fd
Abstract: Objective: At least 10% of pheochromocytoma and sympathetic paraganglioma (PPGL) are malignant, yet there is no specific biomarker of malignancy. Societies guidelines sugget the use of 3 Methoxytyramines (3MTT) for the diagnosis of malignancy, however… read more here.
Keywords: diagnosis; sensitivity; malignancy; ppgl ... See more keywords
Hypertension and cardiac damage in pheochromocytoma and paraganglioma patients: a large-scale single-center cohort study
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-024-03936-6
Abstract: Hypertension (HT) is one of the most common manifestations in patients with catecholamine-secreting neuroendocrine tumors. Although the cardiovascular manifestations of these tumors have been described, there have been no large-scale investigations of the profile of… read more here.
Keywords: cohort; history; cardiac damage; ppgl ... See more keywords
Current prospects of hereditary adrenal tumors: towards better clinical management
Sign Up to like & getrecommendations! Published in 2024 at "Hereditary Cancer in Clinical Practice"
DOI: 10.1186/s13053-024-00276-6
Abstract: Adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL) are two rare types of adrenal gland malignancies. Regarding hereditary tumors, some patients with ACC are associated with with Li-Fraumeni syndrome (LFS), and those with PPGL with multiple endocrine… read more here.
Keywords: hereditary adrenal; current prospects; clinical management; ppgl ... See more keywords
Cabozantinib plus atezolizumab in patients with advanced and progressive neuroendocrine neoplasms (NENs): A prospective multi-cohort basket phase II trial (CABATEN / GETNE-T1914).
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.4128
Abstract: 4128 Background: Early results with immune-checkpoint inhibitors (ICI) in NENs when used as single agents achieve limited response rates. Angiogenesis plays a key role in development and progression of NENs and synergism has been observed… read more here.
Keywords: cabozantinib; advanced progressive; basket; plus atezolizumab ... See more keywords
Genetic bases of pheochromocytoma and paraganglioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/endoabs.81.s9.1
Abstract: The genetics of pheochromocytoma and paraganglioma (PPGL) has become increasingly complex over the last two decades. The list of genes involved in the development of these tumors has grown steadily, and there are currently more… read more here.
Keywords: pheochromocytoma paraganglioma; genetic bases; endocrinology; ppgl ... See more keywords
EPAS-1-related pheochromocytoma/paraganglioma: How common and how aggressive?
Sign Up to like & getrecommendations! Published in 2024 at "Endocrine-related cancer"
DOI: 10.1530/erc-23-0303
Abstract: In 2012, somatic EPAS1 pathogenic variants were found to cause a triad of pheochromocytoma/paragangliomas (PPGL), polycythemia and somatostatinoma. Since then, a limited number of studies on this subject have been reported and data on the… read more here.
Keywords: epas1; epas1 related; epas1 pathogenic; ppgl ... See more keywords
Biomarker identification of immune-related genes in pheochromocytoma and paraganglioma
Sign Up to like & getrecommendations! Published in 2023 at "Translational Andrology and Urology"
DOI: 10.21037/tau-22-800
Abstract: Background Although we have a good understanding of the diagnosis and treatment of pheochromocytoma and paraganglioma (PPGL), the underlying pathogenesis and molecular pathways of PPGL need to be further studied. This study aimed to use… read more here.
Keywords: immune related; pheochromocytoma paraganglioma; ppgl; core genes ... See more keywords
Germline Mutations and Phenotypic Associations in Korean Patients With Pheochromocytoma and Paraganglioma: A Multicenter Study and Literature Review
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2023.0376
Abstract: Genetic testing is recommended for all patients with pheochromocytomas and paragangliomas (PPGL) to establish genotype–phenotype associations. We investigated germline mutations in 59 patients with PPGL at six Korean university hospitals using next-generation sequencing (NGS) targeting… read more here.
Keywords: korean patients; germline; ppgl; literature review ... See more keywords
Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.574662
Abstract: Pheochromocytoma/paraganglioma (PPGL) has a high genetic heterogeneity with 40% germline variants in known pathogenic genes. Data in Chinese on this aspect are scanty. To detect the genetic and clinical profile of Chinese PPGL patients, we… read more here.
Keywords: chinese ppgl; genetic clinical; ppgl patients; ppgl ... See more keywords