Treatment and outcomes in pheochromocytomas and paragangliomas: a study of 110 cases from a single center
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1734-x
Abstract: PurposeMany pheochromocytomas and paragangliomas (PPGLs) are nowadays diagnosed as incidentalomas or by screening. This may have changed outcomes.MethodsWe reviewed 110 consecutive cases of PPGLs. Two cases with concurrent ectopic ACTH-syndrome were excluded.ResultsSixty-five percent had presented… read more here.
Keywords: surgery; treatment outcomes; outcomes pheochromocytomas; pheochromocytomas paragangliomas ... See more keywords
Seizures in patients with a phaeochromocytoma/paraganglioma (PPGL): A review of clinical cases and postulated pathological mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Revue neurologique"
DOI: 10.1016/j.neurol.2018.11.007
Abstract: The purpose of this work was to expound on the postulated pathological mechanisms through which pheochromocytoma/paraganglioma (PPGL) can cause seizures by conducting a comprehensive review of ten cases and several pathogenic mechanisms. The goal was… read more here.
Keywords: paraganglioma ppgl; review; pathological mechanisms; ppgl ... See more keywords
SENSITIVITY AND SPECIFICITY OF 24 HOURS URINARY 3-METHOXYTYRAMINES IN THE DIAGNOSIS OF MALIGNANT PHEOCHROMOCYTOMA AND PARAGANGLIOMA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539342.92258.fd
Abstract: Objective: At least 10% of pheochromocytoma and sympathetic paraganglioma (PPGL) are malignant, yet there is no specific biomarker of malignancy. Societies guidelines sugget the use of 3 Methoxytyramines (3MTT) for the diagnosis of malignancy, however… read more here.
Keywords: diagnosis; sensitivity; malignancy; ppgl ... See more keywords
Genetic bases of pheochromocytoma and paraganglioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/endoabs.81.s9.1
Abstract: The genetics of pheochromocytoma and paraganglioma (PPGL) has become increasingly complex over the last two decades. The list of genes involved in the development of these tumors has grown steadily, and there are currently more… read more here.
Keywords: pheochromocytoma paraganglioma; genetic bases; endocrinology; ppgl ... See more keywords
Biomarker identification of immune-related genes in pheochromocytoma and paraganglioma
Sign Up to like & getrecommendations! Published in 2023 at "Translational Andrology and Urology"
DOI: 10.21037/tau-22-800
Abstract: Background Although we have a good understanding of the diagnosis and treatment of pheochromocytoma and paraganglioma (PPGL), the underlying pathogenesis and molecular pathways of PPGL need to be further studied. This study aimed to use… read more here.
Keywords: immune related; pheochromocytoma paraganglioma; ppgl; core genes ... See more keywords
Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.574662
Abstract: Pheochromocytoma/paraganglioma (PPGL) has a high genetic heterogeneity with 40% germline variants in known pathogenic genes. Data in Chinese on this aspect are scanty. To detect the genetic and clinical profile of Chinese PPGL patients, we… read more here.
Keywords: chinese ppgl; genetic clinical; ppgl patients; ppgl ... See more keywords
A Durable Response With the Combination of Nivolumab and Cabozantinib in a Patient With Metastatic Paraganglioma: A Case Report and Review of the Current Literature
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DOI: 10.3389/fendo.2020.594264
Abstract: Introduction Pheochromocytomas and sympathetic paragangliomas (PPGL) are neuroendocrine catecholamine-secreting tumors that are usually localized. Metastatic disease is rare and systemic treatment consists of conventional chemotherapy and high-specific-activity iodine-131-MIBG which was approved by the FDA in… read more here.
Keywords: case; ppgl; cabozantinib; response combination ... See more keywords
PD-L1 expression and association with genetic background in pheochromocytoma and paraganglioma
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DOI: 10.3389/fonc.2022.1045517
Abstract: Metastatic pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors associated with poor prognosis and limited therapeutic options. Recent advances in oncology-related immunotherapy, specifically in targeting of programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathways, have… read more here.
Keywords: pseudohypoxia; expression; cluster; ppgl ... See more keywords
Differential HIF2α Protein Expression in Human Carotid Body and Adrenal Medulla under Physiologic and Tumorigenic Conditions
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DOI: 10.3390/cancers14122986
Abstract: Simple Summary Thoraco-abdominal paraganglioma and pheochromocytoma (PPGL) are pathogenically linked to mutations in SDH genes. Loss-of-function of SDH has been associated with stabilization of HIF2α, which otherwise would be degraded via oxygen-sensitive mechanisms. SDH dysfunction… read more here.
Keywords: carotid body; hif2; ppgl; hnpgl ... See more keywords
Pathophysiology and Management of Glycemic Alterations before and after Surgery for Pheochromocytoma and Paraganglioma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065153
Abstract: Glycemic alterations are frequent in patients with pheochromocytoma and paraganglioma (PPGL), but the real incidence of secondary diabetes mellitus (DM) is uncertain, because prospective multicenter studies on this topic are lacking in the literature. The… read more here.
Keywords: pheochromocytoma paraganglioma; surgery; glycemic alterations; alterations surgery ... See more keywords
The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas: An Update
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DOI: 10.3390/metabo12020131
Abstract: Pheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy,… read more here.
Keywords: non coding; paragangliomas; ppgl; metabolome non ... See more keywords